Synthesis of pH-sensitive sulfonamide-based hydrogels with controllable crosslinking density by post thermo-curing
學年 107
學期 1
出版（發表）日期 2019-01-02
作品名稱 Synthesis of pH-sensitive sulfonamide-based hydrogels with controllable crosslinking density by post thermo-curing
作品名稱（其他語言）
著者 Chih-Yu Kuo; Trong-Ming Don; Yen-Ting Lin; Shih-Chi Hsu; Wen-Yen Chiu
單位
出版者
著錄名稱、卷期、頁數 Journal of Polymer Research 26(1), Article:18
摘要 Sulfonamide-containing linear copolymers were synthesized via copolymerization of N-(4-methacrylamido)-N′-(4,6-dimethylpyrimidin-2-yl) benzene-1-sulfonamide (SAM) and N,N′-dimethylacrylamide (DMAAm) via free-radical polymerization at room temperature using redox initiators. The redox-initiated polymerization could undergo nearly complete reaction in which the copolymer composition was almost the same as the feeding monomer ratio. These linear copolymers could be dissolved in water and displayed pH-sensitive properties around the physiological pH value of human body with a very sharp transition window less than 0.1 pH unit. Moreover, by introducing N-methyloyl acrylamide (NMA) monomer into the reaction system, the resulting copolymers could become crosslinked hydrogels when subjected to post thermo-curing through the NMA units. The crosslinking density and pH-sensitivity could be manipulated by changing the curing time and temperature. Therefore, swelling ratio and gel fraction of hydrogels could be accurately tailored. The pH-sensitive windows of these hydrogels were found to maintain in between 6.80 to 7.40, which implied that these hydrogels would be a suitable candidate for biomedical materials.
關鍵字 Sulfonamidemonomer;Hydrogels;pH-sensitive;Swelling ratio;Crosslinking
語言 en_US
ISSN 1022-9760
期刊性質 國外
收錄於 SCI EI
產學合作
通訊作者 Trong-Ming Don
審稿制度 是
國別 NLD
公開徵稿
出版型式 ,電子版,紙本
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/116002 )