教師資料查詢 | 類別: 期刊論文 | 教師: 董崇民 Don, Trong-ming (瀏覽個人網頁)

標題:Guided bone regeneration activity of different calcium phosphate/chitosan hybrid membranes
學年107
學期2
出版(發表)日期2019/04/01
作品名稱Guided bone regeneration activity of different calcium phosphate/chitosan hybrid membranes
作品名稱(其他語言)
著者Yau-Hung Chen; Hung-Yin Tai; Earl Fu; Trong-Ming Don
單位
出版者
著錄名稱、卷期、頁數International Journal of Biological macromolecules 126, p.159–169
摘要To fulfill the properties of membrane for guided bone tissue regeneration, chitosan (CS) and calcium phosphates were blended to produce porous hybrid membranes by lyophilization. We synthesized three different calcium phosphates: calcium deficient hydroxyapatite (CDHA), biphasic calcium phosphate (BCP) and β‑tricalcium phosphate (TCP) by a reverse emulsion method followed by calcination, and compared their efficacy on bone regeneration. The CDHA/CS, BCP/CS, and TCP/CS membranes had an interconnected pore structure with porosity of 91–95% and pore size of 102–147 μm. These hybrid membranes could promote the permeability and adhesiveness to bone cells as demonstrated by in-vitro cell culture of primary osteoblast. Particularly, the CDHA/CS and BCP/CS could further increase the cell attachment and differentiation, whereas the BCP/CS and TCP/CS could enhance cell proliferation. Finally, these hybrid membranes were assessed for guided bone regeneration in the critical-size calvarial bone defects created in SD rats. Histological and histomorphometric analyses revealed that the BCP/CS membrane had the most effective bone regeneration compared to the other two hybrid membranes. At three-week post-surgery, the BCP/CS membrane could enhance new bone generation up to 57% of the original bone defect area. The BCP/CS membrane thus has the potential to be applied for guided bone
關鍵字Bone regeneration;Chitosan;Calcium phosphate
語言英文(美國)
ISSN
期刊性質國外
收錄於SCI;EI;
產學合作
通訊作者Trong-Ming Don
審稿制度
國別荷蘭
公開徵稿
出版型式,電子版,紙本
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