教師資料查詢 | 類別: 期刊論文 | 教師: 王三郎 WANG SAN-LANG (瀏覽個人網頁)

標題:Isolation and identification of potent antidiabetic compounds from Antrodia cinnamomea - An edible Taiwanese mushroom
學年107
學期1
出版(發表)日期2018/11/02
作品名稱Isolation and identification of potent antidiabetic compounds from Antrodia cinnamomea - An edible Taiwanese mushroom
作品名稱(其他語言)
著者Huang TT; Wang SL; Nguyen VB; Kuo YH
單位
出版者
著錄名稱、卷期、頁數Molecules, 23(11): 2864
摘要Antrodia cinnamomea (AC), an edible Taiwanese mushroom, has been recognized as a
valuable natural resource with vast biological and medicinal benefits. Recently, the hypoglycemic and
anti-diabetic effects of AC were mentioned in several studies. However, no studies have investigated
α-glucosidase inhibitors from AC fruiting bodies (ACFB) as they relate to type 2 diabetes (T2D)
treatment. The purpose of this study was to gain evidence of potent α-glucosidase inhibitory effects,
as well as isolate, identify and characterize the active compounds of ACFB. The MeOH extract
of ACFB demonstrated potent α-glucosidase inhibitory activity, and possessed high pH stability
(pH 2–11) and thermostable properties at 40–50 ◦C. Further purification led to the isolation of eight
constituents from ACFB, identified as: 25S-antcin K (1), 25R-antcin K (2), dehydrosulphurenic acid
(3), 25S-antcin I (4), 25S-antcin B (5), 25R-antcin B (6), dehydroeburicoic acid (7) and eburicoic acid
(8). Notably, the ACFB extract and its identified compounds, except 1, 4, and 6 demonstrated a
greater effect (EC50 = 0.025–0.21 mg/mL) than acarbose (EC50 = 0.278 mg/mL). As such, these active
compounds were determined to be new potent mushroom α-glucosidase inhibitors. These active
compounds were also identified on the HPLC fingerprints of ACFB.
關鍵字Antrodia cinnamomea; antidiabetic; edible mushroom; α-glucosidase inhibitor; antcin K; dehydrosulphurenic acid; dehydroeburicoic acid; eburicoic acid
語言中文
ISSN1420-3049
期刊性質國外
收錄於SCI;
產學合作
通訊作者San-Lang Wang
審稿制度
國別中華民國
公開徵稿
出版型式,電子版
相關連結
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