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標題:The Impact of Pharmacological Treatments on Cognitive Function and Severity of Behavioral Symptoms in Geriatric Elder Patients with Dementia
學年105
學期2
出版(發表)日期2017/03/01
作品名稱The Impact of Pharmacological Treatments on Cognitive Function and Severity of Behavioral Symptoms in Geriatric Elder Patients with Dementia
作品名稱(其他語言)
著者Nian-Sheng Tzeng; Wei-Shan Chiang; Shun-Yi Chen; Yu-Ching Chou; Kun-Ming Lee; San-Yuan Huang; Chin-Bin Yeh; Chun-Yen Chen; Hsin-An Chang; Yu-Chen Kao
單位
出版者
著錄名稱、卷期、頁數Taiwanese Journal of Psychiatry (31)1,p.69-79
摘要This study was to determine the impact of different pharmacological
treatments on cognitive functions and the severity of the behavioral and psychological
symptoms (BPSD) in elderly patients with dementia. Methods: The
study was a prospective, and observational study. We examined 70 older patiens
with dementia with the Mini-Mental Status examination (MMSE) and the Neuropsychiatric
Inventory (NPI) Scale at each time of the outpatient visits at the 1st,
4th, and 12th week, to fi nd out the impacts of antipsychotic drugs, mood stabilizers/antidepressants,
hypno-sedative, and cognitive enhancers/anti-dementia drugs.
Results: The majority of dementia types were Alzheimer’s dementia (AD, n = 40,
57.1%) and vascular dementia (VaD, n = 28, 40%). The caregivers were their
spouses (n = 10, 14.3%), or children (n = 53, 75.7%). We found that psychotropic
medications, 27 (38.6%) of the patients used antipsychotic drugs, 25 (35.7%)
mood stabilizers/antidepressants, 27 (38.6%) hypno-sedatives, and 48 (68.6%)
cognitive enhancers/anti-dementia drugs. Those medications did not show any signifi
cant improvements of the MMSE at 12th weeks. Mood stabilizers/antidepressants
reached a signifi cant decrease in both the NPI severity and the caregiver
distress scores. Conclusion: In this study, we found that patients with BPSD, receiving
antipsychotics, mood stabilizers/antidepressants, hypno-sedative and cognitive
enhancers/anti-dementia drugs did not improve the MMSE scores at the end
of study, but that those receiving mood stabilizer/antidepressants showed a signifi -
cant decrease on the behavioral disturbances measured by the NPI scale.
關鍵字cognitive function;mini-mental status examination;behavioral and psychological symptoms;neuropsychiatric inventory
語言英文
ISSN
期刊性質國內
收錄於
產學合作
通訊作者
審稿制度
國別中華民國
公開徵稿
出版型式,紙本
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