教師資料查詢 | 類別: 期刊論文 | 教師: 王三郎 WANG SAN-LANG (瀏覽個人網頁)

標題:New novel α–glucosidase inhibitors produced by microbial conversion
學年106
學期2
出版(發表)日期2018/02/01
作品名稱New novel α–glucosidase inhibitors produced by microbial conversion
作品名稱(其他語言)
著者Nguyen Van Bon, Wang San-Lang
單位
出版者
著錄名稱、卷期、頁數Process Biochemistry, v.65, p.228-232
摘要Fermented Nutrient Broth (FNB) was found to be a potential source of antidiabetic drugs in the previous report. Thus, FNB was employed to isolate the active compounds in this study. Novel 5 α-glucosidase inhibitors (aGIs) were isolated from FNB and identified as: (1) Adenine, (2) 3-hydroxyproline, (3) Creatinine, (4) Nicotinic acid, and (5) Niacinamide. Notably, these inhibitors were found as new microbial aGIs, non-sugar-based moiety aGIs. Of these inhibitors, compounds 2 and 4 showed activity against rat α-glucosidase equal to, or stronger than, that
of acarbose, with the IC50 values of 100, 67, and 115 μg/mL, respectively. These results contributed to enriching the current poor novel microbial aGIs, and also confirmed that FNB shows promising utilization for diabetes and obesity treatments or health foods due to their containing efficient mammalian aGIs.
關鍵字α–glucosidase inhibitor;Paenibacillus sp.;Diabetes;Microbial conversion
語言英文
ISSN1359-5113
期刊性質國外
收錄於SCI;EI;
產學合作
通訊作者WANG San-Lang
審稿制度
國別美國
公開徵稿
出版型式,電子版
相關連結
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