教師資料查詢 | 類別: 期刊論文 | 教師: 王三郎 WANG SAN-LANG (瀏覽個人網頁)

標題:Isolation and identification of novel α-amylase inhibitors from Euonymus laxiflorus Champ
學年106
學期2
出版(發表)日期2018/02/01
作品名稱Isolation and identification of novel α-amylase inhibitors from Euonymus laxiflorus Champ
作品名稱(其他語言)
著者Nguyen VB, Wang SL*, Nguyen AD, Vo TPK, Zhang LJ, Nguyen QV, Kuo YH
單位
出版者
著錄名稱、卷期、頁數Research on Chemical Intermediates 44(2), pp1411-1424
摘要Euonymus laxiflorus Champ. (ELC) has been reported to possess potential
antidiabetic activity. The aim of this study is to isolate and identify the active
compounds in ELC extract. Application of effective techniques including Diaoin,
octadecylsilane opened columns, dialysis, and preparative high-performance liquid
chromatography (HPLC) coupled with a biologically guided assay resulted in isolation
of 11 novel active compounds. Five compounds were identified as new α-amylase inhibitors (αAIs), viz. walterolactone A/B β-D-pyranoglucoside (1),
schweinfurthinol 9-O-β-D-pyranoglucoside (10), 1-O-(3-methyl)-butenoyl-myoinositol (11), leonuriside (13), and (3,5-dimethoxy-4-hydroxyphenol) -1-O-β-D-(6′-O-galloyl)-glucopyranoside (21). Among these inhibitors, three compounds (1, 10, 11) were characterized as new. Another six known compounds (2, 9, 16, 17, 18, 19) were determined as phenolic. Notably, six compounds (1, 2, 9, 13, 16, 17) demonstrated significant activity, comparable to or higher than that of acarbose, a commercial antidiabetic drug, based on t test ranking. The relationship between the chemical structures and bioactivity of the inhibitors is also reported.
關鍵字α-amylase inhibitor;Euonymus laxiflorus Champ.;Medicinal plants;Diabetes;Obesity;Bioactive compounds
語言英文
ISSN0922-6168
期刊性質國內
收錄於SCI;
產學合作
通訊作者WANG San-Lang
審稿制度
國別美國
公開徵稿
出版型式,電子版
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