教師資料查詢 | 類別: 期刊論文 | 教師: 謝忠宏 HSIEH, CHUNG-HUNG (瀏覽個人網頁)

標題:Introduction of Cysteine Dioxygenase: Structural Biology, Proposed Reaction Mechanisms and Biomimetic Model Complexes
學年102
學期2
出版(發表)日期2014/06/01
作品名稱Introduction of Cysteine Dioxygenase: Structural Biology, Proposed Reaction Mechanisms and Biomimetic Model Complexes
作品名稱(其他語言)
著者Sen-Jer Lee, Jing-Yi Huang, Chung-Hung Hsieh
單位
出版者
著錄名稱、卷期、頁數72卷2期
摘要There is a variety of metalloenzymes in the biological system. The organisms use them to maintain their life. Herein, we introduce a special enzyme: Cysteine Dioxygenase (CDO); CDO is a non-heme iron enzyme, which can convert cysteine (Cys) into cysteine sulfinic acid (CSA). This conversion plays an important role in cysteine catabolism in mammalian tissue. Deficiency of CDO has been correlated with Alzheimer’s, Parkinson’s and other neurological disorders. Structural comparison from the typical non-hemeFe(II) dioxygenases to CDO, the coordination sphere of the Fe in CDO deviates fromthe fac-2-Histeines-1-carboxylate to a 3-Histeines facial triad. Themechanistic information of CDO, involves in O2 activation to generate Fe(III)-O2 − or further leading to the formation of Fe(IV) = O species, is still not clear. Biomimetic studies suggest the S-oxygenation mediatedby an Fe(II)-SR complex and O2 is expectable.
關鍵字Cysteine Dioxygenase, CDO
語言中文
ISSN
期刊性質國內
收錄於
產學合作
通訊作者Chung-Hung Hsieh
審稿制度1
國別中華民國
公開徵稿
出版型式,電子版,紙本
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