Cartilage MRI T2* relaxation time and perfusion changes of the knee in a 5/6 nephrectomy rat model of chronic kidney disease
學年 105
學期 2
出版（發表）日期 2017-06-21
作品名稱 Cartilage MRI T2* relaxation time and perfusion changes of the knee in a 5/6 nephrectomy rat model of chronic kidney disease
作品名稱（其他語言）
著者 Wang, Chao-Ying; Peng, Yi-Jen; Hsu, Yu-Juei; Lee, Herng-Sheng; Chang, Yue-Cune; Chang, C.-S.; Chiang, Shih-Wei; Hsu, Yi-Chih; Lin, Ming-Huang; Huang, Guo-Shu
單位
出版者
著錄名稱、卷期、頁數 Osteoarthritis and Cartilage 25(6), p.976-985
摘要 Objective Chronic kidney disease (CKD) is characterized by metabolic disturbances in calcium and phosphorus homeostasis as kidney function declines. Alterations in blood perfusion in bone resulting from arteriosclerosis of bone vessels may relate to the progression of CKD. Herein, change in dynamic contrast enhanced (DCE) MRI parameters (A: amplitude, kel: elimination constant, and kep: permeability rate constant) and MRI T2∗ relaxation time of the knee cartilage were measured in a rodent nephrectomy model in order to (1) examine the relationship of peripheral blood perfusion to CKD and (2) demonstrate the feasibility of using DCE-MRI parameters and MRI T2∗ as imaging biomarkers to monitor disease progression. Design Two groups of male Sprague–Dawley rats received either (1) no intervention or (2) 5/6 nephrectomy. Results We found that the CKD group (compared with the control group) had lower A and kel values and similar kep value in the lateral and medial articular cartilages beginning at 12 weeks (P < 0.05); statistically significantly higher T2∗ values in the lateral and medial articular cartilages beginning at 18 weeks (P < 0.05); statistically significantly decreased inner luminal diameter of the popliteal artery, and altered structure of the lateral and medial articular cartilages (P < 0.05). Conclusion Perfusion deficiency and CKD may be related. DCE parameters and MRI T2∗ could serve as imaging biomarkers of cartilage degeneration in CKD progression.
關鍵字 Chronic kidney disease;Dynamic contrast enhanced MRI;MRI T2∗ relaxation time;5/6 Nephrectomy;Cartilage;Knee
語言 en
ISSN 1063-4584
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 否
國別 GBR
公開徵稿
出版型式 ,電子版,紙本
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/112721 )