教師資料查詢 | 類別: 期刊論文 | 教師: 王三郎 WANG SAN-LANG (瀏覽個人網頁)

標題:Screening and evaluation of α-glucosidase inhibitors from indigenous medicinal plants in Dak Lak Province, Vietnam
學年105
學期2
出版(發表)日期2017/06/01
作品名稱Screening and evaluation of α-glucosidase inhibitors from indigenous medicinal plants in Dak Lak Province, Vietnam
作品名稱(其他語言)
著者Van Bon Nguyen; Quang Vinh Nguyen; Anh Dzung Nguyen; San-Lang Wang
單位
出版者
著錄名稱、卷期、頁數Research on Chemical Intermediates 43(6),p.3599-3612
摘要α-Glucosidase inhibitors have received much attention due to their important use in treating diabetes mellitus. Although some synthetic α-glucosidase inhibitors have been available for a long time, they often cause various unexpected side effects. Thus, the present study was aimed at finding a safe, natural source of α-glucosidase inhibitors. Twenty-six samples of 22 medicinal plants were collected in the Dak Lak province of Vietnam and evaluated for α-glucosidase inhibitory activity. Trunk bark extract from Euonymus laxiflorus Champ (ELC extract) was selected as the best α-glucosidase inhibitor with the smallest IC50 = 0.36 mg/mL against rat-derived α-glucosidase. This extract had a stronger inhibitory activity against α-glucosidase from Saccharomyces cerevisiae (IC50 = 1.32 µg/mL) and Bacillus stearothermophilus (IC50 = 5.15 µg/mL). The potential inhibition against some other enzymes were tested, and the results showed that the ELC extract did not inhibit fungal cellulase but strongly inhibited porcine α-amylase (IC50 = 6.7 µg/mL). The ELC extract also inhibited the proteases papain and bromelain, with IC50 = 339 µg/mL and IC50 = 226 µg/mL, respectively. The thermal and pH stabilities of the ELC extract were also investigated.
關鍵字α-Glucosidase inhibition; Medicinal plants; Euonymus laxiflorus Champ; Dak Lak
語言英文
ISSN0922-6168
期刊性質國外
收錄於SCI;
產學合作
通訊作者Wang SL
審稿制度
國別美國
公開徵稿
出版型式,電子版
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