教師資料查詢 | 類別: 期刊論文 | 教師: 王三郎 WANG SAN-LANG (瀏覽個人網頁)

標題:Preparation of chitosan nanoparticles by TPP ionic gelation combined with spray drying, and the antibacterial activity of chitosan nanoparticles and a chitosan nanoparticle–amoxicillin complex
學年105
學期2
出版(發表)日期2017/06/01
作品名稱Preparation of chitosan nanoparticles by TPP ionic gelation combined with spray drying, and the antibacterial activity of chitosan nanoparticles and a chitosan nanoparticle–amoxicillin complex
作品名稱(其他語言)
著者Tan Vui Nguyen; Thi Thu Ha Nguyen; San-Lang Wang; Thi Phuong Khanh Vo; Anh Dzung Nguyen
單位
出版者
著錄名稱、卷期、頁數Research on Chemical Intermediates 43(6), p.3527-3537
摘要Chitosan nanoparticles were prepared from chitosan with various
molecular weights by tripolyphosphate (TPP) ionic gelation combined with a spray
drying method. The morphologies and characteristics of chitosan nanoparticles were
determined by TEM, FE-SEM and from their mean sizes and zeta potentials. The
effect of chitosan molecular weight (130, 276, 760 and 1200 cPs) and size of spray
dryer nozzle (4.0, 5.5 and 7.0 lm) on mean size, size distribution and zeta potential
values of chitosan nanoparticles was investigated. The results showed that the mean
size of chitosan nanoparticles was in the range of 166–1230 nm and the zeta
potential value ranged from 34.9 to 59 mV, depending on the molecular weight of
chitosan and size of the spray dryer nozzles. The lower the molecular weight of
chitosan, the smaller the size of the chitosan nanoparticles and the higher the zeta
potential. A test for the antibacterial activity of chitosan nanoparticles (only) and a
chitosan nanoparticle–amoxicillin complex against Streptococcus pneumoniae was
also conducted. The results indicated that a smaller chitosan nanoparticle and higher
zeta potential showed higher antibacterial activity. The chitosan nanoparticle–
amoxicillin complex resulted in improved antibacterial activity as compared to
amoxicillin and chitosan nanopaticles alone. Using a chitosan nanoparticle–amoxicillin
complex could reduce by three times the dosage of amoxicillin while still
completely inhibiting S. pneumoniae.
關鍵字Chitosan nanoparticles Antibacterial activity Amoxicillin Streptococcus pneumoniae I
語言英文
ISSN0922-6168
期刊性質國外
收錄於SCI;
產學合作
通訊作者San-Lang Wang
審稿制度
國別美國
公開徵稿
出版型式,電子版
相關連結
Google+ 推薦功能,讓全世界都能看到您的推薦!