教師資料查詢 | 類別: 期刊論文 | 教師: 蔡志群 Chih-chun Tsai (瀏覽個人網頁)

標題:High Mortality of Cirrhotic Patients with End-Stage Renal Disease
學年104
學期2
出版(發表)日期2016/03/11
作品名稱High Mortality of Cirrhotic Patients with End-Stage Renal Disease
作品名稱(其他語言)
著者Hung, Tsung-Hsing; Tsai, Chen-Chi; Tseng, Kuo-Chih; Tseng, Chih -Wei; Hsieh, Yu-Hsi; Tsai, Chih-Chun; Lee, Hsing-Feng
單位
出版者
著錄名稱、卷期、頁數Medicine 95(10), pp.e3075
摘要Ascites, hepatic encephalopathy (HE), and esophageal variceal bleeding (EVB) are 3 major complications in patients with cirrhosis. Limited data exist with which to evaluate the long-term mortality of end-stage renal disease (ESRD) in cirrhotic patients with or without complications.

The National Health Insurance Database in Taiwan was used to identify patients with cirrhosis hospitalized between January 1, 2007, and December 31, 2007. The study group consisted of 1068 cirrhotic patients with ESRD, and the control group consisted of 10,680 randomly selected cirrhotic patients without baseline renal function impairment.

The overall 1-year and 3-year mortality rates were 48.5% and 73.1% in the ESRD group, and 32.9% and 55.6% in the control group, respectively. After adjusting for other comorbid disorders, the cirrhotic patients with ESRD showed a statistically significant increase in 3-year mortality (hazard ratio [HR], 1.65; P < 0.001). The HR for 3-year mortality of ESRD cirrhotic patients with recurrent complications was 1.98 (P < 0.001), compared to those with no recent or past complications. The HR of ESRD for 3-year mortality was 1.48 (P < 0.001) in cirrhotic patients with ascites, 1.67 (P < 0.001) in patients with EVB, and 1.19 (P = 0.147) in patients with HE.

ESRD increases the mortality rate in patients with cirrhosis. Recurrent complications can account for a 2-fold increase in the 3-year mortality of ESRD cirrhotic patients. ESRD has a smaller impact on the 3-year mortality of cirrhotic patients with HE compared to those with ascites or EVB.
關鍵字
語言英文(美國)
ISSN1536-5964
期刊性質國外
收錄於SCI;
產學合作
通訊作者Lee, Hsing-Feng
審稿制度
國別美國
公開徵稿
出版型式,電子版
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