| Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma | |
|---|---|
| 學年 | 105 |
| 學期 | 1 |
| 出版（發表）日期 | 2017-01-15 |
| 作品名稱 | Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma |
| 作品名稱（其他語言） | |
| 著者 | Yen-Ta Lu; Tien-Ling Chen; Kuo-Song Chang; Chia-Ming Chang; Tsai-Yin Wei; Jen-Wei Liu; Chih-Ang Hsiao; Tzenge-Lien Shih |
| 單位 | |
| 出版者 | |
| 著錄名稱、卷期、頁數 | Bioorganic Medicinal Chemistry 25(2), p.789-794 |
| 摘要 | Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity. |
| 關鍵字 | Benzazole;B16F10 cells;Melanoma;MTS assay;Naphthalimide;Topoisomerase II |
| 語言 | en |
| ISSN | 0968-0896 |
| 期刊性質 | 國外 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | Tzenge-Lien Shih |
| 審稿制度 | 是 |
| 國別 | GBR |
| 公開徵稿 | |
| 出版型式 | ,電子版,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/109027 ) |
| SDGS | 良好健康和福祉,優質教育 |
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