Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma
學年 105
學期 1
出版(發表)日期 2017-01-15
作品名稱 Synthesis of novel C4-benzazole naphthalimide derivatives with potent anti-tumor properties against murine melanoma
作品名稱(其他語言)
著者 Yen-Ta Lu; Tien-Ling Chen; Kuo-Song Chang; Chia-Ming Chang; Tsai-Yin Wei; Jen-Wei Liu; Chih-Ang Hsiao; Tzenge-Lien Shih
單位
出版者
著錄名稱、卷期、頁數 Bioorganic Medicinal Chemistry 25(2), p.789-794
摘要 Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity.
關鍵字 Benzazole;B16F10 cells;Melanoma;MTS assay;Naphthalimide;Topoisomerase II
語言 en
ISSN 0968-0896
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Tzenge-Lien Shih
審稿制度
國別 GBR
公開徵稿
出版型式 ,電子版,紙本
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