教師資料查詢 | 類別: 專書單篇 | 教師: 王彥雯 WANG, CHARLOTTE (瀏覽個人網頁)

標題:Modeling the Association between Clusters of SNPs and Disease Responses.
學年104
學期1
出版(發表)日期2015/12/31
作品名稱Modeling the Association between Clusters of SNPs and Disease Responses.
作品名稱(其他語言)
著者Raffaele Argiento; Alessandra Guglielmi; Chuhsing Kate Hsiao; Fabrizio Ruggeri; Charlotte Wang
單位
出版者Springer International Publishing
著錄名稱、卷期、頁數Nonparametric Bayesian Methods in Biostatistics and Bioinformatics
摘要The aim of the paper is to discuss the association between SNP genotype data and a disease. For genetic association studies, the statistical analyses with multiple markers have been shown to be more powerful, efficient, and biologically meaningful than single marker association tests. As the number of genetic markers considered is typically large, here we cluster them and then study the association between groups of markers and disease. We propose a two-step procedure: first a Bayesian nonparametric cluster estimate under normalized generalized gamma process mixture models is introduced, so that we are able to incorporate the information from a large-scale SNP data with a much smaller number of explanatory variables. Then, thanks to the introduction of a genetic score, we study the association between the relevant disease response and groups of markers using a logit model. Inference is obtained via an MCMC truncation method recently introduced in the literature. We also provide a review of the state of art of Bayesian nonparametric cluster models and algorithms for the class of mixtures adopted here. Finally, the model is applied to genome-wide association study of Crohn’s disease in a case-control setting.
關鍵字
語言英文(美國)
ISBN9783319195186
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