Thermo- and pH-induced self-assembly of P(AA-b-NIPAAm-b-AA) triblock copolymers synthesized via RAFT polymerization
學年 104
學期 2
出版（發表）日期 2016-04-15
作品名稱 Thermo- and pH-induced self-assembly of P(AA-b-NIPAAm-b-AA) triblock copolymers synthesized via RAFT polymerization
作品名稱（其他語言）
著者 Chih-Yu Kuo; Trong-Ming Don; Shih-Chi Hsu; Chia-Fen Lee; Wen-Yen Chiu; Chih-Yuan Huang
單位
出版者
著錄名稱、卷期、頁數 Journal of Polymer Science, Part A: Polymer Chemistry 54(8), pp.1109-1118
摘要 A series of environmentally sensitive ABA triblock copolymers with different block lengths were prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization from acrylic acid (AA) and N-isopropylacrylamide (NIPAAm). The GPC and 1H NMR analyses demonstrated the narrow molecular weight distribution and precise chemical structure of the prepared P(AA-b-NIPAAm-b-AA) triblock copolymers owing to the controlled/living characteristics of RAFT polymerization. The lower critical solution temperature (LCST) of the triblock copolymers could be tailored by adjusting the length of PAA block and controlled by the pH value. Under heating, the triblock copolymers underwent self-assemble in dilute aqueous solution and formed nanoparticles revealed via TEM images. Physically crosslinked nanogels induced by inter-/intra-hydrogen bonding or core-shell micelle particles thus could be obtained by changing environmental conditions. With a well-defined structure and stimuli-responsive properties, the P(AA-b-NIPAAm-b-AA) copolymer is expected to be employed as a nanocarrier for biomedical applications in controlled-drug delivery and targeting therapy.
關鍵字 block copolymer;core-shell particles;nanogels;reversible addition fragmentation chain transfer (RAFT);RAFT polymerization;self-assembly;stimuli–sensitive polymers
語言 en_US
ISSN 0887-624X
期刊性質 國外
收錄於 SCI EI
產學合作
通訊作者 Trong-Ming Don and Wen-Yen Chiu
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/108285 )