| 標題：Porcine pancreatic α-amylase inhibitors from Euonymus laxiflorus Champ |
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| 學年 | 105 |
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| 學期 | 1 |
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| 出版（發表）日期 | 2017/01/01 |
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| 作品名稱 | Porcine pancreatic α-amylase inhibitors from Euonymus laxiflorus Champ |
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| 作品名稱（其他語言） | |
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| 著者 | Nguyen, Van Bon; Nguyen, Anh Dzung; Nguyen, Quang Vinh; Wang, San-Lang |
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| 單位 | |
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| 出版者 | |
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| 著錄名稱、卷期、頁數 | Research on Chemical Intermediates 43(1), p.259–269 |
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| 摘要 | Twenty-six samples of indigenous medicinal plants were collected in Dak Lak Province of Vietnam and evaluated for α-amylase inhibitory activity. Of these samples, trunk bark extract from Euonymus laxiflorus Champ. (ELC extract) showed the greatest α-amylase inhibitory activity with the smallest 50 % inhibitory concentration (IC50) of 6.6 ± 0.6 µg/mL against porcine pancreatic α-amylase. This extract possessed strong inhibitory activity against human saliva α-amylase and slightly lower activity against Bacillus subtilis α-amylase, with IC50 values of 4.2 ± 0.2 and 27.8 ± 1.8 µg/mL, respectively. ELC extract was found to be strongly thermostable, retaining 72–100 % relative activity even after heating at 100 °C for 5 min to 2 h. This extract was also stable at various pH values. These results suggest that ELC extract may be a good candidate for treatment of non-insulin-dependent diabetes mellitus (NIDDM) and obesity. |
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| 關鍵字 | α-Amylase inhibitors;Diabetes;Obesity;Medicinal plants;Euonymus laxiflorus;Champ.;Dak Lak |
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| 語言 | 英文 |
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| ISSN | 0922-6168;1568-5675 |
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| 期刊性質 | 國外 |
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| 收錄於 | SCI; |
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| 產學合作 | |
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| 通訊作者 | Wang, San-Lang |
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| 審稿制度 | 是 |
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| 國別 | 荷蘭 |
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| 公開徵稿 | |
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| 出版型式 | ,電子版 |
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| 相關連結 | |
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