教師資料查詢 | 類別: 期刊論文 | 教師: 張玉坤 Yue-cune Chang (瀏覽個人網頁)

標題:Abnormal Perfusion in Patellofemoral Subchondral Bone Marrow in the Rat Anterior Cruciate Ligament Transection Model of Post-traumatic Osteoarthritis: a Dynamic Contrast-enhanced Magnetic Resonance Imaging Study
學年104
學期1
出版(發表)日期2016/01/01
作品名稱Abnormal Perfusion in Patellofemoral Subchondral Bone Marrow in the Rat Anterior Cruciate Ligament Transection Model of Post-traumatic Osteoarthritis: a Dynamic Contrast-enhanced Magnetic Resonance Imaging Study
作品名稱(其他語言)
著者Ping-Huei Tsai; Herng-Sheng Lee; Tiing Yee Siow; Chao-Ying Wang; Yue-Cune Chang; Ming-Huang Lin; Yi-Chih Hsu; Chian-Her Lee; Hsiao-Wen Chung; Guo-Shu Huang
單位
出版者
著錄名稱、卷期、頁數Osteoarthritis and Cartilage 24(1), pp.129-133
摘要Objective

Although anterior cruciate ligament (ACL) injury is a well-recognized risk factor for developing knee post-traumatic osteoarthritis (PTOA), the process in the patellofemoral (PF) joint after ACL injury is still under-researched. Our aim was to investigate the perfusion changes in PF subchondral bone marrow in the rat ACL transection (ACLX) model of PTOA using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).

Design

Eighteen male Sprague Dawley rats were randomly separated into three groups (n = 6 each group): a normal control group and groups receiving ACLX and sham-surgery, respectively, in the right knee. Perfusion parameters in the patellar and femoral subchondral bone marrows of all rats were measured on DCE-MRI at 0, 4, 8, and 16 weeks after respective treatment. After the last MRI at week 16, the rats were sacrificed and their right knees were harvested for histologic examination. In addition, to observe the long-term histologic change in PF joints, 9 additional rats (n = 3 in each group) were included and sacrificed at week 32 for histologic examination.

Results

In the ACLX group vs the sham and control groups, the perfusion parameters were significantly changed in both patellar and femoral subchondral bone marrows at week 16. Histologic examination revealed cartilage defects in ACLX rats at 32 weeks after surgery.

Conclusions

These data point to a possible functional relationship between subchondral bone marrow perfusion abnormalities and cartilage breakdown in PTOA. Moreover, the perfusion parameters derived from DCE-MRI can potentially serve as biomarkers of early OA.
關鍵字Post-traumatic osteoarthritis; Patellofemoral joint; Anterior cruciate ligament; DCE-MRI; Perfusion; Subchondral bone marrow
語言英文
ISSN
期刊性質國內
收錄於SCI;
產學合作
通訊作者
審稿制度
國別中華民國
公開徵稿
出版型式,電子版
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