教師資料查詢 | 類別: 期刊論文 | 教師: 陳曜鴻 CHEN, YAU-HUNG (瀏覽個人網頁)

標題:Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo
學年104
學期2
出版(發表)日期2016/02/01
作品名稱Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo
作品名稱(其他語言)
著者Yan, De-Yue; Ni, Lin-Kai; Chen, Ho-Lun; Chen, Li-Chou; Chen, Yau-Hung; Cheng, Chien-Chung
單位
出版者
著錄名稱、卷期、頁數Bioorganic & Medicinal Chemistry Letters 26(3), pp.774-777
摘要Direct coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol–norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medicines, which often contain a significant amount of flavonoids and polyphenol analogs.
關鍵字Liposome;Resveratrol;Norcantharidin;Drug delivery;Tadpole structure
語言英文
ISSN0960-894X
期刊性質國外
收錄於SCI;
產學合作
通訊作者Yan, De-Yue; Chen, Yau-Hung; Cheng, Chien-Chung
審稿制度
國別英國
公開徵稿
出版型式,紙本
相關連結
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