A Fourfold Increase of Oesophageal Variceal Bleeding in Cirrhotic Patients with a History of Oesophageal Variceal Bleeding
學年 104
學期 1
出版（發表）日期 2015-11-25
作品名稱 A Fourfold Increase of Oesophageal Variceal Bleeding in Cirrhotic Patients with a History of Oesophageal Variceal Bleeding
作品名稱（其他語言）
著者 Hung, T. H.; Tseng, C. W.; Tsai, C. C.; Lay, C. J.; Tsai, C. C.
單位
出版者
著錄名稱、卷期、頁數 Singapore Medical Journal 2015, p.1-10
摘要 INTRODUCTION: There is no large, recent, population-based data for evaluating the predictors of oesophageal variceal bleeding (OVB) among cirrhotic patients. The aim of this study was to determine the cumulative incidence of OVB among cirrhotic patients and to identify the predictors of OVB occurrence. METHODS: The patient information of 38,172 cirrhotic patients without OVB history who were discharged between 1 January and 31 December 2007 was obtained from the Taiwan National Health Insurance Database for use in this study. All patients were followed up for three years. Death was considered as the competing risk in the calculations of the cumulative incidences and hazard ratios (HRs) of OVB. RESULTS: OVB was present in 2,609 patients (OVB group) and absent in 35,563 patients (non-OVB group) at the time of hospitalisation. During the three-year follow-up period, the cumulative incidence of OVB was 44.5% in the OVB group, while it was 11.3% in the non-OVB group (p < 0.001). Modified Cox's regression analysis showed that the HR of OVB history was 4.42 for OVB occurrence (95% confidence interval [CI] 4.13-4.74). Other predictors for OVB occurrence included hepatocellular carcinoma (HR 1.16, 95% CI 1.09-1.24), young age (HR 0.98, 95% CI 0.98-0.98), ascites (HR 1.46, 95% CI 1.37-1.56), alcohol-related disorders (HR 1.20, 95% CI 1.12-1.28), peptic ulcer bleeding (HR 1.26, 95% CI 1.13-1.41) and diabetes mellitus (HR 1.14, 95% CI 1.06-1.23). CONCLUSION: Cirrhotic patients have a fourfold increased risk of future OVB once they suffered from their first OVB.
關鍵字 cirrhosis;epidemiology;oesophageal variceal bleeding;portal hypertension
語言 en_US
ISSN 0037-5675
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Tsai, C. C.
審稿制度 否
國別 USA
公開徵稿
出版型式 ,電子版
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