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標題:Epitope and Paratope Region Analysis
學年102
學期2
發表日期2014/07/02
作品名稱Epitope and Paratope Region Analysis
作品名稱(其他語言)
著者Ying-Tsang Lo; Tun-Wen Pai; Hui-Huang Hsu; Huai-Kuang Tsai
作品所屬單位
出版者
會議名稱Eighth International Conference on Complex, Intelligent and Software Intensive Systems (CISIS 2014)
會議地點Birmingham, UK
摘要Print
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A conformational epitope (CE) in an antigenic protein is composed of amino acid residues that are spatially near each other on the antigen's surface but discontinuously appeared in sequence. CEs bind their complementary Para topes which are located on the surface areas of B-cell receptors and/or antibodies. CE predication is a challenging research topic, which plays an important and fundamental role for vaccine design and immuno-biological experiments. The aim of this study is to primarily analyze CE epitopes of 163 non-redundant antigen structures based on physical and chemical properties of surface residues. In terms of physical properties, distinguishable geometric features of solid angle and surface rate of amino acids are observed, while for chemical properties, higher energy, hydrophilicity and polarity from verified epitope regions are discovered as well. All these recognized features from verified CEs were thoroughly analyzed and compared for supporting a CE prediction system.
關鍵字bioinformatics;computational geometry;proteins
語言英文
收錄於
會議性質國際
校內研討會地點
研討會時間20140702~20140704
通訊作者
國別英國
公開徵稿
出版型式
出處Eighth International Conference on Complex, Intelligent and Software Intensive Systems (CISIS 2014), pp.510-514
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