教師資料查詢 | 類別: 會議論文 | 教師: 許輝煌 Hsu Hui-huang (瀏覽個人網頁)

標題:Exclusive Genomic Pathway Analysis for Groupers Infected by Different Iridovirus
學年103
學期2
發表日期2015/07/08
作品名稱Exclusive Genomic Pathway Analysis for Groupers Infected by Different Iridovirus
作品名稱(其他語言)
著者Chun-Cheng Liu; Chien-Ming Chen; Tun-Wen Pai; Hsin-Yiu Chou; Hui-Huang Hsu
作品所屬單位
出版者
會議名稱2015 Ninth International Conference on Complex, Intelligent, and Software Intensive Systems (CISIS-2015)
會議地點Blumenau, Brazil
摘要Grouper is one of the most important aquaculture fish in the world. Due to high density of grouper farming, the aquaculture industry is threatened by iridovirus infections in recent years. In this study, we used next-generation sequencing technologies to analyze gene differential expression of groupers infected by two different types of iridoviruses, including Grouper Iridovirus of Taiwan (TGIV) of Megalocytivirus and Grouper Iridovirus (GIV) of Ranavirus. Zebra fish (Danio rerio) was selected as the reference model for gene functional annotations and pathway analyses. According to different fold change levels and identified associated KEGG pathways from defined gene sets, we found exclusive biological characteristics of groupers infected by two different iridoviruses. The results have shown that two specific gene sets, including the first set of PSMB2, CASP3, and U2AF2 for TGIV and the second set of PTGES, PDE3, and THBS1 for GIV were significantly and exclusively expressed. Furthermore, we also found two important pathways, Proteasome and ECM-receptor interaction pathways, were identified by employing gene set/pathway enrichment analysis. These results could facilitate biologists realizing comprehensive gene regulation of groupers infected by different iridoviruses and developing specific vaccines for grouper aquaculture.
關鍵字aquaculture;genomics
語言英文
收錄於
會議性質國際
校內研討會地點
研討會時間20150708~20150710
通訊作者
國別巴西
公開徵稿
出版型式
出處2015 Ninth International Conference on Complex, Intelligent, and Software Intensive Systems (CISIS-2015), pp.508-512
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