教師資料查詢 | 類別: 期刊論文 | 教師: 鄧金培 DENG,JIN-PEI (瀏覽個人網頁)

標題:Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice
學年104
學期1
出版(發表)日期2015/11/15
作品名稱Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice
作品名稱(其他語言)
著者Ranjith Kumar Kankala; Yaswanth Kuthati; Huei-Wun Sie; Hung-Yuan Shih; Sheng-I Lue; Shravankumar Kankala; Chien-Chung Jeng,Jin-Pei Deng; Ching-Feng Weng; Chen-Lun Liu; Chia-Hung Lee
單位
出版者
著錄名稱、卷期、頁數Journal of Colloid and Interface Science 458, pp.217–228
摘要Multiple layers of pH-sensitive enteric copolymers were coated over layered double hydroxide (LDH) nanoparticles for controllable drug release and improved solubility of hydrophobic drugs. The nano-sized LDH carriers significantly improved the accessibility of sulfasalazine molecules that have positively charged frameworks. In addition, the successful encapsulation of negatively charged enteric copolymers was achieved via electrostatic attractions. The multi-layered enteric polymer coating could potentially protect nanoparticle dissolution at gastric pH and accelerate the dissolution velocity, which would improve the drug bioavailability in the colon. Next, biological studies of this formulation indicated a highly protective effect from the scavenging of superoxide free radicals and diethyl maleate (DEM) induced lipid peroxidation, which are major cell signalling pathways for inflammation. The histological view of the liver and kidney sections revealed that the nanoformulation is safe and highly biocompatible. The animal studies conducted via paw inflammation induced by complete Freund’s adjuvant (CFA) revealed that enteric-coated LDH-sulfasalazine nanoparticles provided a sustained release that maintained the sulfasalazine concentrations in a therapeutic window. Therefore, this nanoformulation exhibited preferential efficacy in reducing the CFA-induced inflammation especially at day 4.
關鍵字Layered double hydroxides;Nanoparticles;Oral drug delivery;Sulfasalazine;Eudragit copolymer;Inflammatory
語言英文(美國)
ISSN1095-7103
期刊性質國外
收錄於SCI;
產學合作
通訊作者Chen-Lun Liu; Chia-Hung Lee
審稿制度
國別美國
公開徵稿
出版型式,電子版,紙本
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