教師資料查詢 | 類別: 期刊論文 | 教師: 莊子超 Chuang, Tzu-chao (瀏覽個人網頁)

標題:Growth-suppressive effect of berberine on endometrial carcinoma cells: Role of mitochondrial and PI3K/Akt pathway
學年104
學期1
出版(發表)日期2015/08/01
作品名稱Growth-suppressive effect of berberine on endometrial carcinoma cells: Role of mitochondrial and PI3K/Akt pathway
作品名稱(其他語言)
著者Han-Peng Kuo; Yi-Jen Lee; Chih-Yu Hsu; Shou-Lun Lee; Shih-Chung Hsu; Tzu-Chao Chuange; Jah-Yao Liuf; Chao-Lin Kuo; Chi-Tang Ho; Ming-Ching Kao
單位
出版者
著錄名稱、卷期、頁數Journal of Functional Foods 17, pp.600-609
摘要Berberine is an isoquinoline alkaloid and a popular dietary supplement in the US market for lowering blood glucose and managing a healthy lipid profile. The anti-tumour activity of berberine is also known. Endometrial cancer is a gynecological malignancy tumour. Our study demonstrated for the first time that berberine could be used to inhibit endometrial carcinoma cell proliferation in vitro and unveiled the relevant mechanisms. By flow cytometry, we found that berberine affected cell cycle distribution in endometrial cancer cells. Additionally, berberine could induce cell apoptosis through activation of the mitochondrial/caspase pathway. We further investigated berberine-mediated signal transduction in endometrial cancer cells and found that berberine engaged in the PI3K/Akt pathway, a cell proliferation- and cell cycle progression-related signalling pathway. Our results suggest that berberine could be used as a potential dietary supplement or functional food ingredient to prevent endometrial cancer.
關鍵字Berberine;Endometrial cancer;Dietary supplement;Functional food ingredient;PI3K/Akt pathway
語言英文
ISSN1756-4646;2214-9414
期刊性質國外
收錄於SCI;
產學合作
通訊作者
審稿制度
國別荷蘭
公開徵稿
出版型式,電子版,紙本
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