教師資料查詢 | 類別: 期刊論文 | 教師: 溫啟仲 WEN,CHI-CHUNG (瀏覽個人網頁)

標題:Profiling time course expression of virus genes - An illustration of Bayesian inference under shape restrictions
學年98
學期1
出版(發表)日期2009/12/01
作品名稱Profiling time course expression of virus genes - An illustration of Bayesian inference under shape restrictions
作品名稱(其他語言)
著者Chien, Li-Chu; Chang, I-Shou; Jiang, Shih-Sheng; Gupta, Pramod K.; Wen, Chi-Chung; Wu, Yuh-Jenn; Hsiung, Chao A.
單位淡江大學數學學系
出版者Beachwood: Institute of Mathematical Statistics
著錄名稱、卷期、頁數The Annals of Applied Statistics 3(4), pp.1542-1565
摘要There have been several studies of the genome-wide temporal transcriptional program of viruses, based on microarray experiments, which are generally useful in the construction of gene regulation network. It seems that biological interpretations in these studies are directly based on the normalized data and some crude statistics, which provide rough estimates of limited features of the profile and may incur biases. This paper introduces a hierarchical Bayesian shape restricted regression method for making inference on the time course expression of virus genes. Estimates of many salient features of the expression profile like onset time, inflection point, maximum value, time to maximum value, area under curve, etc. can be obtained immediately by this method. Applying this method to a baculovirus microarray time course expression data set, we indicate that many biological questions can be formulated quantitatively and we are able to offer insights into the baculovirus biology.
關鍵字Baculovirus; Bernstein polynomials; genome-wide expression profile; Markov chain Monte Carlo; microarray experiments; shape restricted regression
語言英文
ISSN1932-6157
期刊性質國外
收錄於SCI
產學合作
通訊作者
審稿制度
國別美國
公開徵稿
出版型式紙本
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