教師資料查詢 | 類別: 期刊論文 | 教師: 溫啟仲 WEN,CHI-CHUNG (瀏覽個人網頁)

標題:Protective Role of Comfrey Leave Extracts on UV-induced Zebrafish Fin Damage
學年102
學期2
出版(發表)日期2014/07/01
作品名稱Protective Role of Comfrey Leave Extracts on UV-induced Zebrafish Fin Damage
作品名稱(其他語言)
著者Cheng, Chien-Chung; Chou, Chi-Yuan; Chang, Yao-Chin; Wang, Hsuan-Wen; Wen, Chi-Chung; Chen, Yau-Hung
單位淡江大學數學學系; 淡江大學化學學系
出版者Tokyo: Japanese Society of Toxicologic Pathology
著錄名稱、卷期、頁數Journal of Toxicologic Pathology 27(2), pp.115-121
摘要In zebrafish, UV exposure leads to fin malformation phenotypes including fin reduction or absence. The present study evaluated UV-protective activities of comfrey leaves extracts in a zebrafish model by recording fin morphological changes. Chemopreventive effects of comfrey leave extracts were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. The results showed that (1) the mean times of return to normal fin in the UV+comfrey (50 and 100 ppm) groups were 3.43 and 2.86 days and were quicker compared with that in the UV only group (4.21 days); (2) zebrafish fins in the UV+comfrey (50 and 100 ppm) groups were 2.05 and 3.25 times more likely to return to normal than those in the UV only group; and (3) comfrey leave extracts had UV-absorbance abilities and significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, comfrey leaves extracts may have the potential to be developed as UV-protective agents to protect zebrafish embryos from UV-induced damage.
關鍵字comfrey;fin;UV;zebrafish
語言英文
ISSN0914-9198
期刊性質國外
收錄於SCI;
產學合作
通訊作者Cheng, Chien-Chung; Chen, Yau-Hung
審稿制度
國別日本
公開徵稿
出版型式,紙本
相關連結
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