教師資料查詢 | 類別: 會議論文 | 教師: 陳以錚 YI-CHENG CHEN (瀏覽個人網頁)

標題:Comparative analysis of 3D-culture system for murine neonatal heart regeneration: a systematic approach for big gene expression data
學年102
學期2
發表日期2014/05/13
作品名稱Comparative analysis of 3D-culture system for murine neonatal heart regeneration: a systematic approach for big gene expression data
作品名稱(其他語言)
著者Weng, Julia Tzu-Ya; Chen, Yi-Cheng; Chang, Pei-Chann; Huang, Shin-Ping; Chiu, Yu-Wei
作品所屬單位淡江大學資訊工程學系
出版者Springner
會議名稱The 1st International Workshop on Pattern Mining and Application of Big Data (BigPMA 2014) (in conjunction with PAKDD 2014)
會議地點Tainan, Taiwan
摘要Cardiovascular diseases are the leading cause of death worldwide. Loss or dysfunction of cardiomyocytes is associated with many forms of heart disease. The adult mammalian heart has a limited regenerative ability after damage, leading to the formation of fibrotic scar tissues, hypertrophy, contractile dysfunction and ul-timately, organ failure. In contrast, neonatal mammalian cardiomyocytes retain a significant replenishing potential briefly after birth. There is increasing enthusiasm to grow neonatal cardiomyocytes in 3D culture systems to artificially restore heart function. Various scaffolds and matrices are available, but the molecular and cellu-lar mechanisms underlying proliferation and differentiation of neonatal mammalian cardiomyocytes are not very well understood. Here, we utilize a systematic strategy to analyze the extensive genome-scale gene expression profiles of two different 3D constructs. We present a comprehensive comparison that may help improve the protocols for growing cardiomyocytes in a 3D culture system.
關鍵字cardiomyocytes;regeneration;3-D culture system;gene expression;bioinformatics
語言英文(美國)
收錄於EI
會議性質國際
校內研討會地點
研討會時間20140513~20140516
通訊作者Weng, Julia Tzu-Ya
國別中華民國
公開徵稿Y
出版型式電子版
出處Lecture Notes in Artificial Intelligence 8643, pp.754-764
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