教師資料查詢 | 類別: 期刊論文 | 教師: 陳以錚 YI-CHENG CHEN (瀏覽個人網頁)

標題:MicroRNA Expression Profiling Altered by Variant Dosage of Radiation Exposure
學年103
學期1
出版(發表)日期2014/08/16
作品名稱MicroRNA Expression Profiling Altered by Variant Dosage of Radiation Exposure
作品名稱(其他語言)
著者Lee, Kuei-Fang; Chen, Yi-Cheng; Hsu, Paul Wei-Che; Liu, Ingrid Y.; Wu, Lawrence Shih-Hsin
單位淡江大學資訊工程學系
出版者New York: Hindawi Publishing Corporation
著錄名稱、卷期、頁數BioMed Research International 2014, 456323(10pages)
摘要Various biological effects are associated with radiation exposure. Irradiated cells may elevate the risk for genetic instability, mutation, and cancer under low levels of radiation exposure, in addition to being able to extend the postradiation side effects in normal tissues. Radiation-induced bystander effect (RIBE) is the focus of rigorous research as it may promote the development of cancer even at low radiation doses. Alterations in the DNA sequence could not explain these biological effects of radiation and it is thought that epigenetics factors may be involved. Indeed, some microRNAs (or miRNAs) have been found to correlate radiation-induced damages and may be potential biomarkers for the various biological effects caused by different levels of radiation exposure. However, the regulatory role that miRNA plays in this aspect remains elusive. In this study, we profiled the expression changes in miRNA under fractionated radiation exposure in human peripheral blood mononuclear cells. By utilizing publicly available microRNA knowledge bases and performing cross validations with our previous gene expression profiling under the same radiation condition, we identified various miRNA-gene interactions specific to different doses of radiation treatment, providing new insights for the molecular underpinnings of radiation injury.
關鍵字
語言英文(美國)
ISSN2314-6141
期刊性質國外
收錄於SCI;EI;
產學合作
通訊作者Lee, Kuei-Fang
審稿制度
國別美國
公開徵稿
出版型式,電子版,紙本
相關連結
Google+ 推薦功能,讓全世界都能看到您的推薦!