教師資料查詢 | 類別: 期刊論文 | 教師: 陳以錚 YI-CHENG CHEN (瀏覽個人網頁)

標題:Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure
學年102
學期2
出版(發表)日期2014/07/21
作品名稱Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure
作品名稱(其他語言)
著者Lee, Kuei-Fang; Weng, Julia Tzu-Ya; Hsu, Paul Wei-Che; Chi, Yu-Hsiang; Chen, Ching-Kai; Liu, Ingrid Y.; Chen, Yi-Cheng; Wu, Lawrence Shih-Hsin
單位淡江大學資訊工程學系
出版者New York: Hindawi Publishing Corporation
著錄名稱、卷期、頁數BioMed Research International 2014, 834087(9 pages)
摘要Though damage caused by radiation has been the focus of rigorous research, the mechanisms through which radiation exerts harmful effects on cells are complex and not well-understood. In particular, the influence of low dose radiation exposure on the regulation of genes and pathways remains unclear. In an attempt to investigate the molecular alterations induced by varying doses of radiation, a genome-wide expression analysis was conducted. Peripheral blood mononuclear cells were collected from five participants and each sample was subjected to 0.5 Gy, 1 Gy, 2.5 Gy, and 5 Gy of cobalt 60 radiation, followed by array-based expression profiling. Gene set enrichment analysis indicated that the immune system and cancer development pathways appeared to be the major affected targets by radiation exposure. Therefore, 1 Gy radioactive exposure seemed to be a critical threshold dosage. In fact, after 1 Gy radiation exposure, expression levels of several genes including FADD, TNFRSF10B, TNFRSF8, TNFRSF10A, TNFSF10, TNFSF8, CASP1, and CASP4 that are associated with carcinogenesis and metabolic disorders showed significant alterations. Our results suggest that exposure to low-dose radiation may elicit changes in metabolic and immune pathways, potentially increasing the risk of immune dysfunctions and metabolic disorders.
關鍵字
語言英文(美國)
ISSN2314-6141
期刊性質國外
收錄於SCI;EI;
產學合作
通訊作者Lee, Kuei-Fang
審稿制度
國別美國
公開徵稿
出版型式,電子版,紙本
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