Structure characterizations and protein resistance of chitosan membranes selectively crosslinked by poly(ethylene glycol) dimethacrylate
學年 102
學期 2
出版（發表）日期 2014-03-08
作品名稱 Structure characterizations and protein resistance of chitosan membranes selectively crosslinked by poly(ethylene glycol) dimethacrylate
作品名稱（其他語言）
著者 Cheng, Chia-Chu; Mi, Fwu-Long; Hsu, Shan-hui; Don, Trong-Ming
單位 淡江大學化學工程與材料工程學系暨研究所
出版者 Dordrecht: Springer Netherlands
著錄名稱、卷期、頁數 Cellulose 21(3), pp.1431-1444
摘要 Chitosan (CS) is a fragile material with a high modulus of elasticity. Improving its flexibility as well as membrane permeability are the key aspects that need to be addressed for using CS as a biomaterial. Poly(ethylene glycol) (PEG) has several unique properties such as protein resistance, low toxicity, immunogenicity, and good solubility in both water and organic solvents. In this study, a vinyl compound was grafted to the C-6 position of CS by protection-grafting-deprotection. The vinyl CS was then crosslinked with PEG dimethacrylate (PEGDMA) selectively at its C-6 position to form CS-g-PEG copolymer membranes. Analyses from spectra of Fourier-transform infrared and nuclear magnetic resonance confirmed the chemical structure of the crosslinking CS-g-PEG copolymer membranes. Thermal and mechanical properties of the prepared CS-g-PEG membranes were measured and well-correlated to their structures. The incorporation of PEGDMA into the CS increased the material’s flexibility and thermal resistance. Finally, the CS-g-PEG membranes were found to have good protein resistance and blood compatibility; therefore, it has potential application as the biomedical material especially for hemodialysis.
關鍵字 Chitosan;Poly(ethylene glycol) dimethacrylate;Copolymer membrane;Protein resistance
語言 en
ISSN 1572-882X
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Don, Trong-Ming
審稿制度 是
國別 NLD
公開徵稿
出版型式 ,電子版,紙本
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