教師資料查詢 | 類別: 期刊論文 | 教師: 潘伯申 PO-SHEN PAN (瀏覽個人網頁)

標題:Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction
學年102
學期2
出版(發表)日期2014/03/04
作品名稱Direct synthesis of the arylboronic acid analogues of phenylglycine via microwave-assisted four-component Ugi reaction
作品名稱(其他語言)
著者Lian, Ru-Ching; Lin, Meng-Hsuan; Liao, Pin-Hsuan; Fu, Jia-Jie; Wu, Meng-Ju; Wu, Yang-Chang; Chang, Fang-Rong; Wu, Chin-Chung; Pan, Po-Shen
單位淡江大學化學學系
出版者Kidlington: Pergamon Press
著錄名稱、卷期、頁數Tetrahedron 70(9), pp.1800–1804
摘要A four-component Ugi reaction (Ugi-4CR) utilizing formylphenyl boronic acids under mild condition was developed for the synthesis of arylboronic acid analogs. The reactions were performed in methanol and accelerated by microwave irradiation, which makes this strategy suitable for constructing boronic-containing chemical libraries. Two of the synthesized analogs were found to have cytotoxic activity against HepG2, MDA-MB231, and A549 cancer cell lines, demonstrating the potential application of this approach in developing novel boron-containing pharmaceuticals.
關鍵字
語言英文
ISSN0040-4020
期刊性質國外
收錄於SCI;
產學合作
通訊作者Pan, Po-Shen
審稿制度
國別英國
公開徵稿
出版型式,紙本
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