教師資料查詢 | 類別: 期刊論文 | 教師: 許輝煌 Hsu Hui-huang (瀏覽個人網頁)

標題:Identification of Simple Sequence Repeat Biomarkers through Cross-Species Comparison in a Tag Cloud Representation
學年102
學期2
出版(發表)日期2014/03/31
作品名稱Identification of Simple Sequence Repeat Biomarkers through Cross-Species Comparison in a Tag Cloud Representation
作品名稱(其他語言)
著者Huang, Jhen-Li; Chang, Hao-Teng; Cheng, Ronshan; Hsu, Hui-Huang; Pai, Tun-Wen
單位淡江大學資訊工程學系
出版者America: Hindawi Publishing Corporation
著錄名稱、卷期、頁數BioMed Research International 2014(2014), 678971(11pages)
摘要Simple sequence repeats (SSRs) are not only applied as genetic markers in evolutionary studies but they also play an important role in gene regulatory activities. Efficient identification of conserved and exclusive SSRs through cross-species comparison is helpful for understanding the evolutionary mechanisms and associations between specific gene groups and SSR motifs. In this paper, we developed an online cross-species comparative system and integrated it with a tag cloud visualization technique for identifying potential SSR biomarkers within fourteen frequently used model species. Ultraconserved or exclusive SSRs among cross-species orthologous genes could be effectively retrieved and displayed through a friendly interface design. Four different types of testing cases were applied to demonstrate and verify the retrieved SSR biomarker candidates. Through statistical analysis and enhanced tag cloud representation on defined functional related genes and cross-species clusters, the proposed system can correctly represent the patterns, loci, colors, and sizes of identified SSRs in accordance with gene functions, pattern qualities, and conserved characteristics among species.
關鍵字
語言英文
ISSN2314-6141
期刊性質國外
收錄於SCI
產學合作
通訊作者
審稿制度
國別美國
公開徵稿
出版型式電子版;紙本
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