教師資料查詢 | 類別: 期刊論文 | 教師: 黃國楨 Hwang, Kuo-Jen (瀏覽個人網頁)

標題:Immobilization of heparin on PVDF membranes with microporous structures
學年93
學期1
出版(發表)日期2004/12/01
作品名稱Immobilization of heparin on PVDF membranes with microporous structures
作品名稱(其他語言)
著者Lin, Dar-jong; Lin, Dong-tsamn; Young, Tai-horng; Huang, Fang-ming; Chen, Ching-chung; Cheng, Liao-ping
單位淡江大學化學工程與材料工程學系
出版者
著錄名稱、卷期、頁數Journal of membrane science 245(1-2), pp.137-146
摘要Heparin (an anti-thrombin) was immobilized onto microporous poly (vinylidene fluoride) (PVDF) membranes that were prepared either by dry or immersion precipitation method. Immobilization of heparin was carried out by a procedure consisted of two steps. First, poly (acrylic acid) (PAA) was grafted on PVDF membranes with various surface porosities by plasma-induced polymerization. Then, heparin was covalently bonded to PAA with the aid of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (EDAC). The highest attainable grafting yield of PAA was 0.68 mg/cm2. For heparin immobilization, it was found that the preparation parameters such as, EDAC activation time, concentration of reactants, and pH affected significantly the amount of immobilized heparin. The maximal value was 9.68 μg/cm2. Furthermore, blood compatibility tests were carried out on membranes with and without heparin by platelet adhesion method. The results indicated that immobilized-heparin could effectively inhibit platelet adhesion on the membranes.
關鍵字Composite membranes; Plasma polymerized membranes; Immobilization; Heparin
語言英文
ISSN
期刊性質國外
收錄於SCI;EI;
產學合作
通訊作者
審稿制度
國別中華民國
公開徵稿
出版型式,電子版
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