教師資料查詢 | 類別: 期刊論文 | 教師: 溫啟仲 WEN,CHI-CHUNG (瀏覽個人網頁)

標題:Caffeine treatment disturbs the angiogenesis of zebrafish embryos
學年101
學期1
出版(發表)日期2012/10/01
作品名稱Caffeine treatment disturbs the angiogenesis of zebrafish embryos
作品名稱(其他語言)
著者Yeh, C.H.; Liao, Y.F.; Chang, C.Y.; Tsai, J.N.; Wang, Y.H.; Cheng, C.C.; Wen, C.C.; Chen, Y.H.
單位淡江大學數學學系暨研究所
出版者New York: Informa Healthcare
著錄名稱、卷期、頁數Drug and Chemical Toxicology 35(4), pp.361-5
摘要Caffeine is a widely consumed substance that occurs in numerous dietary sources, but teratogenic effects of caffeine intake during embryonic development are still not clear. In the present study, we used the zebrafish as a model to assess caffeine-induced toxicity on embryonic vascular development. A green fluorescent vascular endothelium transgenic line, Tg(fli1:egfp), was utilized for the sensitive detection of vascular development, including vasculo- and angiogenesis. Caffeine-treated embryos showed no defects in vasculogenesis, but revealed dose-dependent (250-350 ppm) developmental defects in intersegmental vessels, dorsal longitudinal anastomotic vessels, and subintestinal vein sprouting. Further, real-time polymerase chain reaction analysis of caffeine-treated embryos showed an upregulation of nrp1a along with a downregulation of sema3aa and sema3c. In conclusion, caffeine treatment induces defects of angiogenesis in zebrafish embryos.
關鍵字
語言英文(美國)
ISSN0148-0545;1525-6014
期刊性質國外
收錄於SCI
產學合作國外
通訊作者
審稿制度
國別美國
公開徵稿
出版型式紙本;電子版
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