教師資料查詢 | 類別: 期刊論文 | 教師: 溫啟仲 WEN,CHI-CHUNG (瀏覽個人網頁)

標題:Flavone is efficient to protect zebrafish fins from UV-induced damage
學年100
學期2
出版(發表)日期2012/07/01
作品名稱Flavone is efficient to protect zebrafish fins from UV-induced damage
作品名稱(其他語言)
著者Tsai, I.T.; Yang, Z.S.; Lin, Z.Y.; Wen, C.C.; Cheng, C.C.; Chen, Y.H.
單位淡江大學數學學系暨研究所
出版者New York: Informa Healthcare
著錄名稱、卷期、頁數Drug and Chemical Toxicology 35(3), pp.341-46
摘要We used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids.
關鍵字
語言英文(美國)
ISSN0148-0545;1525-6014
期刊性質國外
收錄於SCI
產學合作
通訊作者
審稿制度
國別美國
公開徵稿
出版型式電子版
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