教師資料查詢 | 類別: 期刊論文 | 教師: 陳曜鴻 CHEN, YAU-HUNG (瀏覽個人網頁)

標題:Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model
學年102
學期1
出版(發表)日期2014/01/01
作品名稱Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model
作品名稱(其他語言)
著者Lee, Ya-Ting; Fong, Tsorng-Harn; Chen, Hui-Min; Chang, Chao-Yuan; Wang, Yun-Hsin; Chern, Ching-Yuh; Chen, Yau-Hung
單位淡江大學化學學系
出版者Basel: M D P I AG
著錄名稱、卷期、頁數Molecules 19, pp.641-650
摘要The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a–d were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment. Results showed that embryos treated with 3'-hydroxychalcone
(compound 1b) displayed a high percentage of muscle defects (96.6%), especially myofibril misalignment. Ultrastructural analysis revealed that compound 1b-treated embryos displayed many muscle defect phenotypes, including breakage and collapse of myofibrils, reduced cell numbers, and disorganized thick (myosin) and thin (actin) filaments. Taken together, our results provide in vivo evidence of the myotoxic effects of the synthesized chalcone analogues on developing zebrafish embryos.
關鍵字chalcone; embryogenesis; muscle; toxicity; zebrafish
語言英文(美國)
ISSN1420-3049
期刊性質國外
收錄於SCI
產學合作
通訊作者
審稿制度
國別瑞士
公開徵稿
出版型式電子版
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