教師資料查詢 | 類別: 會議論文 | 教師: 董崇民 Don, Trong-ming (瀏覽個人網頁)

標題:Synthesis and Characterization of Chitosan membrane Selectively Crosslinked by Poly(ethylene glycol) Dimethacrylate
學年102
學期1
發表日期2013/10/04
作品名稱Synthesis and Characterization of Chitosan membrane Selectively Crosslinked by Poly(ethylene glycol) Dimethacrylate
作品名稱(其他語言)
著者Cheng, Chia-Chu; Mi, Fwu-Long; Don, Trong-Ming
作品所屬單位淡江大學化學工程與材料工程學系
出版者
會議名稱10th International Conference of the Asian Pacific Chitin Chitosan Symposium (10th APCCS)
會議地點Yonago, Japan
摘要In this study, poly(ethylene glycol) dimethacrylate (PEGDMA) was used to crosslink chitosan (CS) chains selectively at the C-6 position of pyranose. Before the crosslinking reaction, the amino group at the C-2 position was protected by reaction with phthalic anhydride (PA) to form phthaloylated chitosan (PACS). From the results of elemental analysis, the degree of substitution was calculated to be 0.88, indicating most amino groups were converted to phthalimide groups. Subsequently, 3-isopropenyl-α,α-dimethylbenzyl isocyanate (TMI), a vinyl compound containing an isocyanate group, was used to react with the PACS, preferentially with the hydroxyl group at the C-6 position. The reaction with TMI thus provided multiple double bonds along the CS chain. The phthalimide group was then reduced to the original amino group by the hydrazine solution at 80oC. Finally, the vinyl CS was crosslinked with PEGDMA at the C-6 position by a UV-initiated free-radical polymerization. FTIR and NMR were used to analyze the chemical structure of PEG-crosslinked CS. Thermal and mechanical properties of the PEG-crosslinked CS membrane were measured and related to their structures. The PEGDMA-crosslinked CS membrane has potential applications as a biomedical material.
關鍵字
語言英文
收錄於
會議性質國際
校內研討會地點
研討會時間20131004~20131008
通訊作者
國別日本
公開徵稿Y
出版型式電子版
出處10th International Conference of the Asian Pacific Chitin Chitosan Symposium, pp. 249
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