教師資料查詢 | 類別: 期刊論文 | 教師: 張玉坤 Yue-cune Chang (瀏覽個人網頁)

標題:Association Between Plasma Endothelin-1 and Severity of Different Types of Glaucoma
學年101
學期2
出版(發表)日期2013/02/01
作品名稱Association Between Plasma Endothelin-1 and Severity of Different Types of Glaucoma
作品名稱(其他語言)
著者Chen, Hsin-Yi; Chang, Yue-Cune; Chen, Wen-Chi; Lane, Hsien-Yuan
單位淡江大學數學學系
出版者Philadelphia: Lippincott Williams &; Wilkins
著錄名稱、卷期、頁數Journal of Glaucoma 22(2), pp.117-122
摘要Purpose: Endothelin-1 (ET-1) has been suggested to play an important role in the pathogenesis of glaucoma. Herein, we studied whether increased levels of plasma ET-1 are associated with changes in the visual field and changes in optical coherence tomography (OCT)-measured retinal nerve fiber layer (RNFL) thickness in patients with different types of glaucoma.

Patients and Methods: Plasma concentration of ET-1 was determined in 31 patients with primary open-angle glaucoma, 18 patients with normal tension glaucoma, 16 patients with primary angle-closure glaucoma, and in 37 normal controls. In all participants, visual field testing was performed and OCT was used to measure RNFL thickness. The correlation between mean ET-1 level and changes in the visual field (mean deviation, dB) and changes in OCT-measured RNFL thickness in 1 randomly selected eye from each patient in each group was then evaluated.

Results: The ET-1 level was 3.27±1.25 pg/mL in the primary open-angle glaucoma group (−14.09±8.76 dB), 3.12±1.46 pg/mL in the normal tension glaucoma group (−8.87±6.15 dB), 2.58±.22pg/mL in the primary angle-closure glaucoma group (−14.55±10.2 dB), and 1.53±1.49 pg/mL in the control group. Although mean ET-1 levels were significantly higher in all 3 of the glaucoma groups than in the control group, there was no significant difference in ET-1 level among the 3 glaucoma groups. In addition, no significant correlation was found between levels of plasma ET-1 and structural or functional changes in patients with different types of glaucoma.

Conclusions: There was no correlation between plasma levels of ET-1 and severity of glaucoma. The role ET-1 plays in the pathogenesis of glaucoma remains to be determined.
關鍵字
語言英文
ISSN1057-0829
期刊性質國外
收錄於SCI
產學合作
通訊作者Chen, Hsin-Yi
審稿制度
國別美國
公開徵稿
出版型式紙本
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