|標題：Association Between Plasma Endothelin-1 and Severity of Different Types of Glaucoma|
|作品名稱||Association Between Plasma Endothelin-1 and Severity of Different Types of Glaucoma|
|著者||Chen, Hsin-Yi; Chang, Yue-Cune; Chen, Wen-Chi; Lane, Hsien-Yuan|
|出版者||Philadelphia: Lippincott Williams & Wilkins|
|著錄名稱、卷期、頁數||Journal of Glaucoma 22(2), pp.117-122|
|摘要||Purpose: Endothelin-1 (ET-1) has been suggested to play an important role in the pathogenesis of glaucoma. Herein, we studied whether increased levels of plasma ET-1 are associated with changes in the visual field and changes in optical coherence tomography (OCT)-measured retinal nerve fiber layer (RNFL) thickness in patients with different types of glaucoma.
Patients and Methods: Plasma concentration of ET-1 was determined in 31 patients with primary open-angle glaucoma, 18 patients with normal tension glaucoma, 16 patients with primary angle-closure glaucoma, and in 37 normal controls. In all participants, visual field testing was performed and OCT was used to measure RNFL thickness. The correlation between mean ET-1 level and changes in the visual field (mean deviation, dB) and changes in OCT-measured RNFL thickness in 1 randomly selected eye from each patient in each group was then evaluated.
Results: The ET-1 level was 3.27±1.25 pg/mL in the primary open-angle glaucoma group (−14.09±8.76 dB), 3.12±1.46 pg/mL in the normal tension glaucoma group (−8.87±6.15 dB), 2.58±.22pg/mL in the primary angle-closure glaucoma group (−14.55±10.2 dB), and 1.53±1.49 pg/mL in the control group. Although mean ET-1 levels were significantly higher in all 3 of the glaucoma groups than in the control group, there was no significant difference in ET-1 level among the 3 glaucoma groups. In addition, no significant correlation was found between levels of plasma ET-1 and structural or functional changes in patients with different types of glaucoma.
Conclusions: There was no correlation between plasma levels of ET-1 and severity of glaucoma. The role ET-1 plays in the pathogenesis of glaucoma remains to be determined.