教師資料查詢 | 類別: 期刊論文 | 教師: 張玉坤 Yue-cune Chang (瀏覽個人網頁)

標題:Temporal MRI Characterization of Gelatin/Hyaluronic Acid/Chondroitin Sulfate Sponge for Cartilage Tissue Engineering
學年102
學期1
出版(發表)日期2013/08/01
作品名稱Temporal MRI Characterization of Gelatin/Hyaluronic Acid/Chondroitin Sulfate Sponge for Cartilage Tissue Engineering
作品名稱(其他語言)
著者Chou, Cheng-Hung; Lee, Herng-Sheng; Tiing Yee Siow, Lin, Ming-Huang; Amit Kumar; Chang, Yue-Cune; Chen Chang; Huang, Guo-Shu
單位淡江大學數學學系
出版者Hoboken: John Wiley & Sons, Inc.
著錄名稱、卷期、頁數Journal of Biomedical Materials Research Part A 101A(8), pp.2174-2180
摘要A tri-copolymer sponge consisting of gelatin, hyaluronic acid, and chondroitin sulfate (GHC) was designed to mimic the cartilage environment in vivo for cartilage regeneration. The present study aimed to temporally characterize the magnetic resonance relaxation time of GHC constructs in vivo in a rodent heterotopic model. GHC sponges with cells (GHCc) or without cells (GHC) implanted in rat leg muscle were monitored using MRI (4.7 T MR scanner) on day 0, 7, 14, and 21 after implantation. The results revealed that the transverse relaxation time (T2) of GHC constructs decreased significantly over time when compared to the T2 of GHCc constructs. However, the longitudinal relaxation time (T1) of GHCc and GHC constructs remained stable. Moreover, hematoxylin and eosin and immunohistochemical staining with antibodies to S100 protein, and types I and II collagen showed that normal morphology, phenotype, and function of chondrocytes were preserved in the GHCc construct. Thus, we concluded that GHC constructs adequately support chondrocyte growth and function. On top of that, T2 may be a useful tool for monitoring cartilage regeneration in GHC constructs. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.
關鍵字MRI;relaxation time;cartilage tissue engineering;scaffold
語言英文(美國)
ISSN1552-4965;1549-3296
期刊性質國外
收錄於SCI
產學合作
通訊作者
審稿制度
國別美國
公開徵稿
出版型式紙本;電子版
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