教師資料查詢 | 類別: 期刊論文 | 教師: 潘伯申 PO-SHEN PAN (瀏覽個人網頁)

標題:Efficient Synthesis of Boron-Containing alpha-Acyloxyamide Analogs via Microwave Irradiation
學年102
學期1
出版(發表)日期2013/08/08
作品名稱Efficient Synthesis of Boron-Containing alpha-Acyloxyamide Analogs via Microwave Irradiation
作品名稱(其他語言)
著者Chai, Chih-Cheng; Liu, Pin-Yi; Lin, Chia-Hung; Chen, Hsien-Chi; Wu, Yang-Chang; Chang, Fang-Rong; Pan, Po-Shen
單位淡江大學化學學系
出版者Basel: M D P I AG
著錄名稱、卷期、頁數Molecules 18(8), pp.9488-9511
摘要In this report, a Passerini three-component reaction utilizing boron-containing carboxylic acids or aldehydes is discussed. The reaction was carried out in water and facilitated by the use of microwave irradiation. This methodology allowed for the efficient formation of a broad range of boron-containing α-acyloxyamides under mild conditions within a short time. Two series of boron-containing α-acyloxyamides were synthesized and subsequently screened for cytotoxicity using the MTT cell viability assay. Two potential lead compounds were found to have potent activity against the HepG2 cancer cell line, demonstrating the potential of this methodology for use in the development of novel pharmaceuticals.
關鍵字boron;multicomponent reaction;Passerini reaction;HepG2
語言英文
ISSN1431-5165;1420-3049
期刊性質國外
收錄於SCI;
產學合作
通訊作者Pan, Po-Shen
審稿制度
國別瑞士
公開徵稿
出版型式,紙本
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