教師資料查詢 | 類別: 期刊論文 | 教師: 陳曜鴻 CHEN, YAU-HUNG (瀏覽個人網頁)

標題:Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish
學年101
學期2
出版(發表)日期2013/05/04
作品名稱Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish
作品名稱(其他語言)
著者Lin, Ming-Der; Lee, Hsun-Tzu; Wang, Szu-Chieh; Li, Han-Ru; Hsien, Hsin-Lun; Cheng, Kai-Wen; Chang, Yu-Di; Huang, Min-Lang; Yu, Jr-Kai; Chen, Yau-Hung
單位淡江大學化學學系
出版者London: BioMed Central Ltd.
著錄名稱、卷期、頁數BMC Developmental Biology 13, 18(13pages)
摘要Background
Phosphatase of regenerating liver (PRL) family is classified as class IVa of protein tyrosine phosphatase (PTP4A) that removes phosphate groups from phosphorylated tyrosine residues on proteins. PRL phosphatases have been implicated in a number of tumorigenesis and metastasis processes and are highly conserved. However, the understanding of PRL expression profiles during embryonic development is very limited.

Results
In this study, we demonstrated and characterized the comprehensive expression pattern of Drosophila PRL, amphioxus PRL, and zebrafish PRLs during embryonic development by either whole mount immunostaining or in situ hybridization. Our results indicate that Drosophila PRL is mainly enriched in developing mid-guts and central nervous system (CNS) in embryogenesis. In amphioxus, initially PRL gene is expressed ubiquitously during early embryogenesis, but its expression become restricted to the anterior neural tube in the cerebral vesicle. In zebrafish, PRL-1 and PRL-2 share similar expression patterns, most of which are neuronal lineages. In contrast, the expression of zebrafish PRL-3 is more specific and preferential in muscle.

Conclusions
This study, for the first time, elucidated the embryonic expression pattern of Drosophila, amphioxus, and zebrafish PRL genes. The shared PRL expression pattern in the developing CNS among diverse animals suggests that PRL may play conserved roles in these animals for CNS development.
關鍵字Phosphatase of regenerating liver; PTP4A; Embryogenesis; Drosophila; Zebrafish; Amphioxus
語言英文(美國)
ISSN1471-213X
期刊性質國外
收錄於SCI
產學合作
通訊作者
審稿制度
國別英國
公開徵稿
出版型式電子版
相關連結
Google+ 推薦功能,讓全世界都能看到您的推薦!