教師資料查詢 | 類別: 期刊論文 | 教師: 陳曜鴻 CHEN, YAU-HUNG (瀏覽個人網頁)

標題:Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model
學年101
學期2
出版(發表)日期2013/02/01
作品名稱Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model
作品名稱(其他語言)
著者Chen, Yau-hung; Wang, Wei-Hua; Wang, Yun-Hsin; Lin, Zi-Yu; Wen, Chi-Chung; Chern, Ching-Yuh
單位淡江大學數學學系;淡江大學化學學系
出版者Basel: M D P I AG
著錄名稱、卷期、頁數Molecules 18(2), pp.2052-2060
摘要The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.
關鍵字anti-inflammation; chalcone; fin; zebrafish
語言英文
ISSN1431-5165;1420-3049
期刊性質國外
收錄於SCI;
產學合作
通訊作者Chen, Yau-hung; Chern, Ching-Yuh
審稿制度
國別瑞士
公開徵稿
出版型式,電子版,紙本
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