教師資料查詢 | 類別: 期刊論文 | 教師: 陳曜鴻 CHEN, YAU-HUNG (瀏覽個人網頁)

標題:Amikacin-induced Fin Reduction is Mediated by Autophagy
學年101
學期2
出版(發表)日期2013/03/01
作品名稱Amikacin-induced Fin Reduction is Mediated by Autophagy
作品名稱(其他語言)
著者Tsai, I-Ting; Chen, Yau-Hung; Wang, Yun-Hsin
單位淡江大學生命科學研究所
出版者Tokyo: Japanese Society of Toxicologic Pathology
著錄名稱、卷期、頁數Journal of Toxicologic Pathology 26(1), pp.79-82
摘要Despite its medical use, little is known about the mechanisms underlying amikacin-induced embryotoxicity, including fin reduction, in zebrafish. In this study, we examined the expression of well-known autophagy markers mTOR (target of rapamycin), atg10 (autophagy-related gene), atg12 and LC3 (mammalian homolog of Atg8) in amikacin-treated zebrafish embryos. Our results indicated that the mRNA expression level of atg12 in the amikacin-treated group was significantly increased by 1.5-fold (p<0.05) compared with the corresponding mock control group, while the expression levels of atg10 and mTOR were significantly decreased by 0.74-fold (p<0.05) and 0.58-fold (p<0.05), respectively. Western blot analysis revealed that LC3 protein expression was induced by amikacin. Taken together, these data suggest that amikacin-induced fin reduction is mediated by fin cell autophagy.
關鍵字amikacin; autophagy; embryotoxicity; fin reduction; zebrafish
語言英文(美國)
ISSN0914-9198;1347-7404
期刊性質國外
收錄於SCI;
產學合作
通訊作者Chen, Yau-Hung; Wang, Yun-Hsin
審稿制度
國別日本
公開徵稿
出版型式,電子版,紙本
相關連結
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