教師資料查詢 | 類別: 期刊論文 | 教師: 鄭建中 CHIEN-CHUNG CHENG (瀏覽個人網頁)

標題:Novel Water-Soluble 4,4-Disubstituted Ruthenium(III)-Salen Complexes in DNA Stranded Scission
學年87
學期1
出版(發表)日期1998/10/01
作品名稱Novel Water-Soluble 4,4-Disubstituted Ruthenium(III)-Salen Complexes in DNA Stranded Scission
作品名稱(其他語言)
著者鄭建中; Cheng, Chien-chung; 呂燕凌; Lu, Yen-ling
單位淡江大學化學學系
出版者臺北市中國化學學會
著錄名稱、卷期、頁數Journal of the Chinese Chemical Society=中國化學會會誌 45(5), pp.611-617
摘要Salen-type Ru(III) complexes are found to be capable of reacting with physiologically acceptable oxidants. The water solubility and DNA affinity of these Ru(III)-salen complexes are enhanced by the utilization of a variety of charged groups through the formation of peptide bonds. In the presence of hydrogen peroxide, modified Ru(III)-salen complexes are capable of nicking DNA. In addition, the reactivity in DNA cleavage increases along with the total number of positive charges retaining in Ru( III)-salen complexes and less influence in the electronic effect. Using /sup 32/P-end-labeled oligonucleotides and high resolution polyacrylamide gel electrophoresis, Ru(III)-salen complexes are found to randomly cleave DNA regardless of the DNA secondary conformation such as bulge, inter-loop, or double-stranded regions. The possible reactive species of Ru(III)-salen complexes in DNA cleavage is considered as the hydroxyl radical and high valent oxoruthenium (IV) species according to the UV titration, quenching studies, and reaction with varied oxidants.
關鍵字
語言英文
ISSN0009-4536
期刊性質國內
收錄於SCI;
產學合作
通訊作者鄭建中; Cheng, Chien-chung
審稿制度
國別中華民國
公開徵稿
出版型式,紙本
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