| Novel Water-Soluble 4,4-Disubstituted Ruthenium(III)-Salen Complexes in DNA Stranded Scission | |
|---|---|
| 學年 | 87 |
| 學期 | 1 |
| 出版（發表）日期 | 1998-10-01 |
| 作品名稱 | Novel Water-Soluble 4,4-Disubstituted Ruthenium(III)-Salen Complexes in DNA Stranded Scission |
| 作品名稱（其他語言） | |
| 著者 | 鄭建中; Cheng, Chien-chung; 呂燕凌; Lu, Yen-ling |
| 單位 | 淡江大學化學學系 |
| 出版者 | 臺北市：中國化學學會 |
| 著錄名稱、卷期、頁數 | Journal of the Chinese Chemical Society=中國化學會會誌 45(5), pp.611-617 |
| 摘要 | Salen-type Ru(III) complexes are found to be capable of reacting with physiologically acceptable oxidants. The water solubility and DNA affinity of these Ru(III)-salen complexes are enhanced by the utilization of a variety of charged groups through the formation of peptide bonds. In the presence of hydrogen peroxide, modified Ru(III)-salen complexes are capable of nicking DNA. In addition, the reactivity in DNA cleavage increases along with the total number of positive charges retaining in Ru( III)-salen complexes and less influence in the electronic effect. Using /sup 32/P-end-labeled oligonucleotides and high resolution polyacrylamide gel electrophoresis, Ru(III)-salen complexes are found to randomly cleave DNA regardless of the DNA secondary conformation such as bulge, inter-loop, or double-stranded regions. The possible reactive species of Ru(III)-salen complexes in DNA cleavage is considered as the hydroxyl radical and high valent oxoruthenium (IV) species according to the UV titration, quenching studies, and reaction with varied oxidants. |
| 關鍵字 | |
| 語言 | en |
| ISSN | 0009-4536 |
| 期刊性質 | 國內 |
| 收錄於 | SCI |
| 產學合作 | |
| 通訊作者 | 鄭建中; Cheng, Chien-chung |
| 審稿制度 | 否 |
| 國別 | TWN |
| 公開徵稿 | |
| 出版型式 | ,紙本 |
| 相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/61670 ) |
GoogleAnalytics