教師資料查詢 | 類別: 期刊論文 | 教師: 吳漢銘 Han-ming Wu (瀏覽個人網頁)

標題:Clustering by neurocognition for fine mapping of the schizophrenia susceptibility loci on chromosome 6p
學年98
學期1
出版(發表)日期2009/11/01
作品名稱Clustering by neurocognition for fine mapping of the schizophrenia susceptibility loci on chromosome 6p
作品名稱(其他語言)
著者Lin, S.-H.; Liu, C.-M.; Liu, Y.-L.; Fann, C. Shen-Jang; Hsiao, P.-C.; Wu, J.-Y.; Hung, S.-I.; Chen, C.-H.; Wu, H.-M.; Jou, Y.-S.; Liu, S. K.; Hwang, T. J.; Hsieh, M. H.; Chang, C.-C.; Yang, W.-C.; Lin, J.-J.; Chou, F. H.-C.; Faraone, S. V.; Tsuang, M. T.; Hwu, H.-G.; Chen, W. J.
單位淡江大學數學學系
出版者Malden: Wiley-Blackwell Publishing, Inc.
著錄名稱、卷期、頁數Genes, Brain and Behavior 8(8), pp.785–794
摘要Chromosome 6p is one of the most commonly implicated regions in the genome-wide linkage scans of schizophrenia, whereas further association studies for markers in this region were inconsistent likely due to heterogeneity. This study aimed to identify more homogeneous subgroups of families for fine mapping on regions around markers D6S296 and D6S309 (both in 6p24.3) as well as D6S274 (in 6p22.3) by means of similarity in neurocognitive functioning. A total of 160 families of patients with schizophrenia comprising at least two affected siblings who had data for eight neurocognitive test variables of the continuous performance test (CPT) and the Wisconsin card sorting test (WCST) were subjected to cluster analysis with data visualization using the test scores of both affected siblings. Family clusters derived were then used separately in family-based association tests for 64 single nucleotide polymorphisms (SNPs) covering the region of 6p24.3 and 6p22.3. Three clusters were derived from the family-based clustering, with deficit cluster 1 representing deficit on the CPT, deficit cluster 2 representing deficit on both the CPT and the WCST, and a third cluster of nondeficit. After adjustment using false discovery rate for multiple testing, SNP rs13873 and haplotype rs1225934-rs13873 on BMP6-TXNDC5 genes were significantly associated with schizophrenia for the deficit cluster 1 but not for the deficit cluster 2 or nondeficit cluster. Our results provide further evidence that the BMP6-TXNDC5 locus on 6p24.3 may play a role in the selective impairments on sustained attention of schizophrenia.
關鍵字Candidate gene;cluster analysis;endophenotype;executive dysfunction;schizophrenia;sustained attention deficit
語言英文
ISSN1601-183X
期刊性質國外
收錄於SCI
產學合作
通訊作者Chen, W. J.
審稿制度
國別美國
公開徵稿
出版型式電子版
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