Synthesis and characterization of stimuli-responsive porous/hollow nanoparticles by self-assembly of chitosan-based graft copolymers and application in drug release
學年 98
學期 2
出版（發表）日期 2010-06-01
作品名稱 Synthesis and characterization of stimuli-responsive porous/hollow nanoparticles by self-assembly of chitosan-based graft copolymers and application in drug release
作品名稱（其他語言）
著者 Chuang, Chung-Yang; Don, Trong-Ming; Chiu, Wen-Yen
單位 淡江大學化學工程與材料工程學系
出版者 Hoboken: John Wiley & Sons, Inc.
著錄名稱、卷期、頁數 Journal of Polymer Science Part A: Polymer Chemistry 48(11), pp.2377–2387
摘要 In this research, stimuli-responsive porous/hollow nanoparticles were prepared by the self-assembly method. First, chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) copolymers were synthesized through polymerization of N-isopropylacrylamide (NIPAAm) monomer in the presence of chitosan (CS) solution using ceric ammounium nitrate as the initiator. Then, the CS-g-PNIPAAm copolymers were dissolved in the acetic acid aqueous solution and heated to 40 °C to induce their self-assembly. After CS-g-PNIPAAm assembled to form micelles, a cross-linking agent was used to reinforce the structure to form nanoparticles. The molecular weight of grafted PNIPAAm on CS chains was changed to investigate its effect on the structure, morphology, thermo-, and pH-responsive properties of the nanoparticles. TEM images showed that a porous or hollow structure in the interior of nanoparticles was developed, depending on the medium temperature. The synthesized nanoparticles carried positive charges on the surface and exhibited stimuli-responsive properties, and their mean diameter thus could be manipulated by changing the pH value and temperature of the environment. The nanoparticles showed a continuous release of the encapsulated doxycycline hyclate up to 10 days during an in vitro release experiment. These porous/hollow particles with environmentally sensitive properties are expected to be used in hydrophilic drug delivery system.
關鍵字 graft copolymers; nanoparticles; polysaccharides; self-assembly; stimuli-response
語言 en
ISSN 1099-0518
期刊性質 國外
收錄於 SCI EI
產學合作
通訊作者 Chiu, Wen-Yen
審稿制度
國別 USA
公開徵稿
出版型式 電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/60172 )

機構典藏連結