Isolation and Identification of a Novel Antioxidant with Antitumour Activity from Serratia ureilytica Using Squid Pen as Fermentation Substrate
學年 99
學期 2
出版（發表）日期 2011-06-01
作品名稱 Isolation and Identification of a Novel Antioxidant with Antitumour Activity from Serratia ureilytica Using Squid Pen as Fermentation Substrate
作品名稱（其他語言）
著者 Kuo, Yao-Haur; Liang, Tzu-Wen; Liu, Kao-Cheng; Hsu, Ya-Wen; ,Hsu, Hsiu-Ching; Wang, San-Lang
單位 淡江大學化學學系
出版者 New York: Springer New York LLC
著錄名稱、卷期、頁數 Marine Biotechnology 13(3), p.451-461
摘要 The antioxidant activity of the culture supernatant of Serratia ureilytica TKU013 with squid pen as the sole carbon/nitrogen source was assessed by three methods, and the phenolic contents were assayed. The supernatant with the highest antioxidant activity was further purified by liquid–liquid partition, revealing the ethyl acetate extract exhibited the strongest antioxidant activity and the highest total phenolic content. Eight fractions were retrieved from silica gel column chromatography of this extract, designated F1–F8. F4 was found to possess the strong antioxidative activity and the highest total phenolic content and also exhibited strong cytotoxic activities against two different tumoural cell lines. A new compound (Serranticin) with antioxidant and antitumor activity was obtained from F4. The structure of Serranticin is analogous to that of siderophores (hexacoordinated catecholamine), which are iron chelators. As such, Serranticin has the potential for use as a deferration agent in various iron overload diseases.
關鍵字 α-amylase inhibitor;Euonymus laxiflorus Champ.;Medicinal plants;Diabetes;Obesity;Bioactive compounds
語言 en
ISSN 1436-2228;1436-2236
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Wang, San-Lang
審稿制度 否
國別 USA
公開徵稿
出版型式 ,紙本
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