教師資料查詢 | 類別: 期刊論文 | 教師: 陳曜鴻 CHEN, YAU-HUNG (瀏覽個人網頁)

標題:An Alternative Synthesis of 3′,4′-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae
學年100
學期2
出版(發表)日期2012/07/01
作品名稱An Alternative Synthesis of 3′,4′-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae
作品名稱(其他語言)
著者Shih, Tzenge-Lien; Hsiao, Chih-Ang; Lin, Zi-Yu; Chen, Yau-Hung
單位淡江大學化學學系
出版者Basel: M D P I AG
著錄名稱、卷期、頁數Molecules 17(7), pp.8206-8216
摘要We described herein a concise synthesis of 3′,4′-diaminoflavone 10. This new, three-step synthetic approach is more efficient than the conventional seven-step synthetic method. The route is shortened significantly by introducing the amino moieties early and eliminating the need for nitro group reduction. The other two analogues, 5,7-dihydroxy-3′,4′-diaminoflavone 11 and 5,7-dimethoxy-3′,4′-diaminoflavone 12, were also synthesized similarly. The above three compounds, along with flavone, were evaluated for their antioxidant and UVB-protection abilities on zebrafish larvae. The data showed that compound 10 exhibited the best result, with −102.3% of ROS-scavenging rate.
關鍵字antioxidant; Baker-Venkataraman; rearrangement; diaminoflavones; ROS-scavenging; zebrafish larvae
語言英文(美國)
ISSN1431-5165;1420-3049
期刊性質國外
收錄於SCI
產學合作
通訊作者Shih, Tzenge-Lien; Chen, Yau-Hung
審稿制度
國別瑞士
公開徵稿
出版型式電子版;紙本
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