教師資料查詢 | 類別: 期刊論文 | 教師: 陳曜鴻 CHEN, YAU-HUNG (瀏覽個人網頁)

標題:Cardiac Myosin Binding Protein C and MAP-Kinase Activating Death Domain-Containing Gene Polymorphisms and Diastolic Heart Failure
學年100
學期2
出版(發表)日期2012/04/01
作品名稱Cardiac Myosin Binding Protein C and MAP-Kinase Activating Death Domain-Containing Gene Polymorphisms and Diastolic Heart Failure
作品名稱(其他語言)
著者Wu, Cho-Kai; Huang, Yin-Tsen; Lee, Jen-Kuang; Chiang, Liang-Ting; Chiang, Fu-Tien; Huang, Shu-Wei; Lin, Jiunn-Lee; Tseng, Chuen-Den; Chen, Yau-Hung; Tsai, Chia-Ti
單位淡江大學化學學系
出版者San Francisco: Public Library of Science
著錄名稱、卷期、頁數PLoS ONE 7(4), pp.1-6
摘要Objective: Myosin binding protein C (MYBPC3) plays a role in ventricular relaxation. The aim of the study was to investigate the association between cardiac myosin binding protein C (MYBPC3) gene polymorphisms and diastolic heart failure (DHF) in a human case-control study.
Methods: A total of 352 participants of 1752 consecutive patients from the National Taiwan University Hospital and its affiliated hospital were enrolled. 176 patients diagnosed with DHF confirmed by echocardiography were recruited. Controls were matched 1-to-1 by age, sex, hypertension, diabetes, renal function and medication use. We genotyped 12 single nucleotide polymorphisms (SNPs) according to HapMap Han Chinese Beijing databank across a 40 kb genetic region containing the MYBPC3 gene and the neighboring DNA sequences to capture 100% of haplotype variance in all SNPs with minor allele frequencies ≥5%. We also analyzed associations of these tagging SNPs and haplotypes with DHF and linkage disequilibrium (LD) structure of the MYBPC3 gene.
Results: In a single locus analysis, SNP rs2290149 was associated with DHF (allele-specific p = 0.004; permuted p = 0.031). The SNP with a minor allele frequency of 9.4%, had an odds ratio 2.14 (95% CI 1.25-3.66; p = 0.004) for the additive model and 2.06 for the autosomal dominant model (GG+GA : AA, 95% CI 1.17-3.63; p = 0.013), corresponding to a population attributable risk fraction of 12.02%. The haplotypes in a LD block of rs2290149 (C-C-G-C) was also significantly associated with DHF (odds ratio 2.10 (1.53-2.89); permuted p = 0.029). Conclusions: We identified a SNP (rs2290149) among the tagging SNP set that was significantly associated with early DHF in a Chinese population.
關鍵字GENETIC polymorphisms;MUSCLE proteins;VITAMIN K-dependent proteins;POLYMORPHISM (Zoology);BLOOD coagulation factors;CIRCULATING anticoagulants;CARRIER proteins
語言英文
ISSN1932-6203
期刊性質國外
收錄於SCI
產學合作
通訊作者Chen, Yau-Hung
審稿制度
國別美國
公開徵稿
出版型式電子版
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