Flavone is efficient to protect zebrafish fins from UV-induced damages
學年 100
學期 2
出版（發表）日期 2012-07-01
作品名稱 Flavone is efficient to protect zebrafish fins from UV-induced damages
作品名稱（其他語言）
著者 Tsai, I-Ting; Yang, Zhi-Shiang; Lin, Zi-Yu; Wen, Chi-Chung; Cheng, Chien-Chung; Chen, Yau-Hung
單位 淡江大學數學學系; 淡江大學化學學系
出版者
著錄名稱、卷期、頁數 Drug and Chemical Toxicology 35(3), p.341-346
摘要 We used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids.
關鍵字 Chalcone;fin;flavone;UV;xebrafish
語言 en_US
ISSN 0148-0545
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Chen, Yau-Hung
審稿制度 是
國別 USA
公開徵稿
出版型式 ,紙本
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