Flavone is efficient to protect zebrafish fins from UV-induced damages | |
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學年 | 100 |
學期 | 2 |
出版(發表)日期 | 2012-07-01 |
作品名稱 | Flavone is efficient to protect zebrafish fins from UV-induced damages |
作品名稱(其他語言) | |
著者 | Tsai, I-Ting; Yang, Zhi-Shiang; Lin, Zi-Yu; Wen, Chi-Chung; Cheng, Chien-Chung; Chen, Yau-Hung |
單位 | 淡江大學數學學系; 淡江大學化學學系 |
出版者 | |
著錄名稱、卷期、頁數 | Drug and Chemical Toxicology 35(3), p.341-346 |
摘要 | We used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids. |
關鍵字 | Chalcone;fin;flavone;UV;xebrafish |
語言 | en_US |
ISSN | 0148-0545 |
期刊性質 | 國外 |
收錄於 | SCI |
產學合作 | |
通訊作者 | Chen, Yau-Hung |
審稿制度 | 是 |
國別 | USA |
公開徵稿 | |
出版型式 | ,紙本 |
相關連結 |
機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/79659 ) |