| 標題：Flavone is efficient to protect zebrafish fins from UV-induced damages |
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| 學年 | 100 |
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| 學期 | 2 |
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| 出版（發表）日期 | 2012/07/01 |
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| 作品名稱 | Flavone is efficient to protect zebrafish fins from UV-induced damages |
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| 作品名稱（其他語言） | |
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| 著者 | Tsai, I-Ting; Yang, Zhi-Shiang; Lin, Zi-Yu; Wen, Chi-Chung; Cheng, Chien-Chung; Chen, Yau-Hung |
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| 單位 | 淡江大學數學學系; 淡江大學化學學系 |
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| 出版者 | |
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| 著錄名稱、卷期、頁數 | Drug and Chemical Toxicology 35(3), pp.341-346. |
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| 摘要 | We used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids. |
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| 關鍵字 | Chalcone; fin; flavone; UV; zebrafish |
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| 語言 | 英文(美國) |
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| ISSN | 0148-0545 |
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| 期刊性質 | 國外 |
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| 收錄於 | SCI |
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| 產學合作 | |
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| 通訊作者 | Chen, Yau-Hung |
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| 審稿制度 | 是 |
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| 國別 | 美國 |
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| 公開徵稿 | |
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| 出版型式 | 紙本 |
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| 相關連結 | |
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