教師資料查詢 | 類別: 期刊論文 | 教師: 陳曜鴻 CHEN, YAU-HUNG (瀏覽個人網頁)

標題:Molecular structure and developmental expression of zebrafish atp2a genes
學年99
學期1
出版(發表)日期2011/01/01
作品名稱Molecular structure and developmental expression of zebrafish atp2a genes
作品名稱(其他語言)
著者Lai, Yen-Yu; Pai, Chiung-Wen; Tsai, I-Ting; Chou, Chi-Yuan; Tsai, Chia-Ti; Chen, Yau-Hung
單位淡江大學化學學系
出版者Seoul: Genetics Society of Korea
著錄名稱、卷期、頁數Genes & Genomics 33(5), pp.541-548
摘要We isolated two atp2a genes, atp2a1 and atp2a2a, from embryonic zebrafish. Amino acid sequences deduced from zebrafish atp2a genes are aligned with orthologue proteins from other species, the results showed that they share high percentage of identities (82%–94%) and acidic pIs (5.03–5.33). Whole mount in situ hybridization experiments showed that atp2a1 and atp2a2a are maternal inherited genes which can be detected at 1-cell stage embryos and express in the entire animal pole from 6 hours post-fertilization (hpf) to 12 hpf. At the later stages (48–96 hpf), expression of atp2a1 was restricted in head and trunk muscles as well as in some neurons. In contrast to the strongly expression of atp2a1 in head muscle, expression of atp2a2a was detected in head muscle in a fainter manner. In addition, transcripts of atp2a2a were observed in the developing heart during early cardiogenesis. The present studies not only help us to comparatively analyze atp2a genes across species, but also provide useful information about expressions during early embryogenesis that will help in further investigations of functional studies of Atp2a in the future.
關鍵字Calcium; Cardiogenesis; Muscle; SERCA; Zebrafish
語言英文
ISSN1976-9571; 2092-9293
期刊性質國外
收錄於SCI
產學合作
通訊作者Tsai, Chia-Ti; Chen, Yau-Hung
審稿制度
國別韓國
公開徵稿
出版型式紙本
相關連結
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