教師資料查詢 | 類別: 期刊論文 | 教師: 董崇民 Don, Trong-ming (瀏覽個人網頁)

標題:Synthesis and properties of chitosan-based thermo- and pH-responsive nanoparticles and application in drug release
學年97
學期2
出版(發表)日期2009/06/01
作品名稱Synthesis and properties of chitosan-based thermo- and pH-responsive nanoparticles and application in drug release
作品名稱(其他語言)
著者Chuang, Chung-Yang; Don, Trong-Ming; Chiu, Wen-Yen
單位淡江大學化學工程與材料工程學系
出版者Hoboken: John Wiley & Sons, Inc.
著錄名稱、卷期、頁數Journal of Polymer Science Part A: Polymer Chemistry 47(11), pp.2798–2810
摘要In this research, thermo- and pH-responsive nanoparticles with an average diameter of about 50–200 nm were synthesized via the surfactant-free emulsion polymerization. The thermal/pH dual responsive properties of these nanoparticles were designed by the addition of a pH sensitive monomer, acrylic acid (AA), to be copolymerized with N-isopropylacrylamide (NIPAAm) in a chitosan (CS) solution. The molar ratio of CS/AA/NIPAAm in the feed was changed to investigate its effect on structure, morphology, thermal- and pH-responsive properties of the nanoparticles. It was found that CS-PAA-PNIPAAm nanoparticles could be well dispersed in the aqueous solution and carried positive charges on the surface. The addition of thermal-sensitive NIPAAm monomer affected the polymerization mechanism and interactions between CS and AA. The particle size of the nanoparticles was found to be varied with the composition of NIPAAm monomer in the feed. The synthesized nanoparticles exhibited stimuli-responsive properties, and their mean diameter thus could be manipulated by changing pH value and temperature of the environment. The nanoparticles showed a continuous release of the encapsulated doxycycline hyclate up to 10 days during an in vitro release experiment. The environmentally responsive nanoparticles are expected to be used in many fields such as drug delivery system.
關鍵字acrylic acid; chitosan; drug delivery systems; emulsion polymerization; N-isopropylacrylamide; nanoparticles; stimuli-sensitive polymers; thermo/pH response
語言英文
ISSN1099-0518
期刊性質國外
收錄於SCI;EI
產學合作
通訊作者Chiu, Wen-Yen
審稿制度
國別美國
公開徵稿
出版型式電子版
相關連結
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