Synthesis and properties of chitosan-based thermo- and pH-responsive nanoparticles and application in drug release
學年 97
學期 2
出版（發表）日期 2009-06-01
作品名稱 Synthesis and properties of chitosan-based thermo- and pH-responsive nanoparticles and application in drug release
作品名稱（其他語言）
著者 Chuang, Chung-Yang; Don, Trong-Ming; Chiu, Wen-Yen
單位 淡江大學化學工程與材料工程學系
出版者 Hoboken: John Wiley & Sons, Inc.
著錄名稱、卷期、頁數 Journal of Polymer Science Part A: Polymer Chemistry 47(11), pp.2798–2810
摘要 In this research, thermo- and pH-responsive nanoparticles with an average diameter of about 50–200 nm were synthesized via the surfactant-free emulsion polymerization. The thermal/pH dual responsive properties of these nanoparticles were designed by the addition of a pH sensitive monomer, acrylic acid (AA), to be copolymerized with N-isopropylacrylamide (NIPAAm) in a chitosan (CS) solution. The molar ratio of CS/AA/NIPAAm in the feed was changed to investigate its effect on structure, morphology, thermal- and pH-responsive properties of the nanoparticles. It was found that CS-PAA-PNIPAAm nanoparticles could be well dispersed in the aqueous solution and carried positive charges on the surface. The addition of thermal-sensitive NIPAAm monomer affected the polymerization mechanism and interactions between CS and AA. The particle size of the nanoparticles was found to be varied with the composition of NIPAAm monomer in the feed. The synthesized nanoparticles exhibited stimuli-responsive properties, and their mean diameter thus could be manipulated by changing pH value and temperature of the environment. The nanoparticles showed a continuous release of the encapsulated doxycycline hyclate up to 10 days during an in vitro release experiment. The environmentally responsive nanoparticles are expected to be used in many fields such as drug delivery system.
關鍵字 acrylic acid; chitosan; drug delivery systems; emulsion polymerization; N-isopropylacrylamide; nanoparticles; stimuli-sensitive polymers; thermo/pH response
語言 en
ISSN 1099-0518
期刊性質 國外
收錄於 SCI EI
產學合作
通訊作者 Chiu, Wen-Yen
審稿制度 是
國別 USA
公開徵稿
出版型式 電子版
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